Fujisawa Pharmaceutical Company, Ltd.

Nippon Rensui Co.

Akihiko Moro

Takeshi Tabata

Soichiro Ide

Ryuji Nagatani

A chromatographic separation apparatus having a packed column comprising a packed layer, a retained liquid layer above the packed layer, and liquid-feed piping connected to a space above the retained liquid layer and having a flow controller: comprising flow-liquid discharge piping being connected to the bottom of the packed column and having a flow controller, a liquid-level detecting element being provided at the top of the packed column, and a plurality of interface-detecting elements being provided at the inside wall of the packed column; and electrical connection being made so that a first electric signal of the height of the packed layer is transmitted from the interface-detecting element to a controller constituted of a signal converter, an electric current generator, an addition-computing element, and an adjuster; and a second electric signal is transferred from the liquid-level detector provided at the top of the column to the adjuster; and output signal is transmitted from the adjuster to the first controller of the liquid-feed piping and the second controller of the discharging piping.

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Tokyo, Japan

Akihiko Moro