Sophia School Corporation

Cellseed, Inc.

Other

Amersham Pharmacia Biotech K.k.

Akihiko Kikuchi

Akira Masuda

Katsumi Kishino

Masayuki Yamato

Teruo Okano

Tatsuya Shimizu

Kazunori Kataoka

Yasuhisa Sakurai

Hideko Kanazawa

Yoshikazu Matsushima

Hidekazu Sekine

Isao Ishikawa

Masato Kanzaki

Takamasa Onuki

Tinatsu Kohno

Hiroto Sekiguchi

Masateru Hasegawa

Mika Utsumi

Ai Kushida

Chie Konno

The problem to be solved by the present invention is to provide a cultured cell sheet having a superior tissue adhesiveness and an excellent flexibility. The problems can be solved by producing the cultured cell sheet in which cells are cultured in the presence of a surfactant protein or a cross-linking inhibitor on a surface of a cell culture support that is coated with a temperature responsive polymer having an upper or lower critical solution temperature ranging from 0&#xb0; C. to 80&#xb0; C. in water, including steps of: adjusting the temperature of the culture medium to a temperature below the lower critical solution temperature or above the upper critical solution temperature; and detaching the cultured cell sheet.

Cultured cell sheet, production method, and tissue repair method using thereof

A group-III nitride structure includes a substrateand a fine wall-shaped structuredisposed to stand on the substratein a vertical direction relative to a surface of the substrateand extending in an in-plane direction of the substrate. The fine wall-shaped structurecontains a group-III nitride semiconductor crystal, and h is larger than d assuming that the height of the fine wall-shaped structureis h and the width of the fine wall-shaped structurein a direction perpendicular to the height direction and the extending direction is d.

Group-III nitride structure including a fine wall-shaped structure containing a group-III nitridesemiconductor crystal and method for producing a group-III nitride structure including a fine wall-shaped structure containing a group-III nitride semiconductor crystal

A method of manufacturing a semiconductor element by forming, on a substrate, columnar crystals of a nitride-base or an oxide-base compound semiconductor, and by using the columnar crystals, wherein on the surface of the substrate, the columnar crystals are grown while ensuring anisotropy in the direction of c-axis, by controlling ratio of supply of Group-III atoms and nitrogen, or Group-II atoms and oxygen atoms, and temperature of crystal growth, so as to suppress crystal growth in the lateral direction on the surface of the substrate.

Columnar crystal containing light emitting element and method of manufacturing the same

The present invention provides a semiconductor optical element array including: a semiconductor substrate having a main surface in which a plurality of concave portions is formed; a mask pattern that is formed on the main surface of the semiconductor substrate and includes a plurality of opening portions provided immediately above the plurality of concave portions; a plurality of fine columnar crystals that is made of a group-III nitride semiconductor grown from the plurality of concave portions to the upper side of the mask pattern through the plurality of opening portions; an active layer that is grown on each of the plurality of fine columnar crystals; and a semiconductor layer covering each of the active layers.

Semiconductor optical element array and method of manufacturing the same

A cultured periodontal membrane cell sheet, produced through a process comprising culturing cells on a cell culture support composed of a base material having its surface coated with a temperature-responsive polymer of 0&ring;C to 80&ring;C upper limit or lower limit critical dissolution temperature in water under specified conditions, (1) regulating the temperature of culture fluid to temperature&#x2267;the upper limit critical dissolution temperature or&#x2266;the lower limit critical dissolution temperature, (2) causing a cultured periodontal membrane cell sheet resulting from the culturing to adhere to a carrier, and (3) detaching the sheet together with the carrier. This cultured periodontal membrane cell sheet has a syndesmotic microstructure, exhibiting extremely high bioadherence to the surface of dental root, and realizes high-density transplant of target cells and positive reconstruction of periodontal tissue. Moreover, through laminating of cell sheets to be transplanted and donating of three-dimensional polarity, highly efficient reconstruction of attachment apparatus can be accomplished, and clinical application thereof to moderate periodontitis, severe periodontitis, gingival recession, etc. is highly promising.

Cultured periodontal ligament cell sheet, process for producing the same and method of use thereof

A III nitride structure includes a filmhaving a surface composed of a metal formed in a predetermined region on the surface of a substrate, and a fine columnar crystalcomposed of at least a III nitride semiconductor formed on the surface of the substrate, wherein the spatial occupancy ratio of the fine columnar crystalis higher on the surface of the substratewhere the filmis not formed than that on the film.

III nitride structure and method for manufacturing III nitride semiconductor fine columnar crystal

A process for producing a cultured multi-layered skin cell sheet is provided.

Epidermal cultured cell sheet, multi-layered cultured skin sheet and processes for producing those sheets

By using a bed material for cell culture having a surface composed of two domains of domain A coated with a temperature-responsive polymer and domain B composed of any one or a combination of a domain coated with a polymer having high affinity with cells, a domain coated with the temperature-responsive polymer in an amount different from the amount of the temperature-responsive polymer of domain A, and a domain coated with a polymer which responds to a temperature different from the temperature to which domain A responds, a method for the co-culture of a plurality of kinds of cells which has heretofore been difficult becomes possible.

Bed material for cell culture, method for co-culture of cell and co-cultured cell sheet obtainable therefrom

To provide chromatographic packings whereby biological components, etc. which cannot be separated by either ion-exchange chromatography or reversed phase chromatography employed alone can be efficiently separated without deteriorating their activities. Use is made of a packing which contains a charged copolymer and makes it possible to change the effective charge density on the surface of a stationary phase by a physical stimulus while fixing a mobile phase to an aqueous system.

Packing material for chromatography having novel characteristic and method for isolation of substance using the same

PTH-amino acids can be analyzed within a short time at a high sensitivity by chromatographically separating said PTH-amino acids with the use of a packing wherein the hydrophilic/hydrophobic balance on the stationary phase surface can be changed by an external signal while fixing the mobile phase to an aqueous system.

Growing community of inventors

Tokyo, Japan

Akihiko Kikuchi