Km Biologics Co., Ltd.

Kumamoto University

National University Corporation Kumamoto University

Akihiko Hosoi

Toshihiro Nakashima

Kenji Soejima

Masaharu Torikai

Yukio Ando

Hirofumi Jono

Yu Su

Tomoyo Takeo

Masayo Ueno

Mineyuki Mizuguchi

Hirofumi Higuchi

A human antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The human antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a human antibody suitable for application to human body.

Anti-transthyretin human antibody

A humanized antibody which comprises a complementarity determining region of an H chain consisting of the amino acid sequence as shown in SEQ ID NOs: 1 to 3 and a complementarity determining region of an L chain consisting of the amino acid sequence as shown in SEQ ID NOs: 4 to 6. The humanized antibody of the present invention has the activity to specifically bind to transthyretin (TTR) with structural change and the activity to inhibit fibrillization of TTR and is a humanized antibody suitable for application to human body.

Anti-transthyretin humanized antibody

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Kumamoto, Japan

Akihiko Hosoi