Kao Corporation

Akihiko Fujii

Ryuji Ochiai

Yusuke Shibuya

Hideo Oominami

Atsushi Suzuki

Noritaka Takahashi

Yoshie Yamasaki

A bone regeneration agent for regenerating a deficient or resorbed bone due to an inflammatory bone resorption disease, containing a niacin compound as an active ingredient.

Bone regeneration agent

Provided is a method for conveniently and rapidly evaluating or selecting an adiponectin secretion regulator. The method for evaluating or selecting an adiponectin secretion regulator includes the following steps (A) to (C): (A) a step of administering a test substance to an experimental animal; (B) a step of inducing a sleep deprivation in the experimental animal; and (C) a step of measuring blood adiponectin level of the animal, and evaluating change of the blood adiponectin level.

Method for evaluation or selection of adiponectin secretion regulator

Provided is a coffee composition which does not generate hydrogen peroxide in the body even if it is taken for long periods of time. The coffee composition has a hydroxyhydroquinone content of 0 to 0.00005 wt. %.

Coffee drink composition

Provided is a coffee composition having an excellent hypotensive effect. The coffee composition has the following components (A) and (B):

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Haga-gun, Japan

Akihiko Fujii