Public University Corporation Yokohama City University

Yokohama City University

Akihide Ryo

Hideki Taniguchi

Takanori Takebe

Takeshi Sasaki

Ichiro Aoki

Mayuko Nishi

Kei Miyakawa

It is intended to provide a cancer stem cell and a method for preparing the same. The present invention provides a method for preparing a pluripotent cancer stem cell, comprising transferring Oct3/4, Sox2, Klf4, and c-Myc genes to an immortalized epithelial cell. The present invention also provides a pluripotent cancer stem cell as prepared by the above method.

Production method for artificial cancer stem cell and induced differentiation method therefor

A method for determining probability that prostate cancer will metastasize, as well as a diagnostic reagent used therefor is disclosed. It was discovered that the percentage that NF-&#x3ba;B-p65/RelA has the 254th amino acid threonine which is phosphorylated is significantly higher in the prostate cancer cells in the cases where the bone metastasis was observed than in the cases where bone metastasis was not observed. Thus, the method for determining probability that prostate cancer will metastasize comprises measuring human NF-&#x3ba;B-p65/RelA in which 254th amino acid threonine is phosphorylated, which human NF-&#x3ba;B-p65/RelA is contained in a prostate tissue separated from human.

Method for determination of prognosis of prostate cancer, and diagnostic agent for use in the method

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Yokohama, Japan

Akihide Ryo