Taiho Pharmaceutical Company Limited

Hisamitsu Pharmaceutical Company, Inc.

Ube Industries, Inc.

Dainippon Ink and Chemicals, Incorporated

Tsumura Co., Ltd.

Akihide Koda

Mitsugi Yasumoto

Ichiro Yamawaki

Mikio Hori

Kanji Noda

Akira Nakagawa

Hiroyuki Ide

Hidetsugu Takagaki

Yuji Yamada

Munehiko Hirano

Nobuyuki Kimura

Masayoshi Abe

Katsuo Takikawa

Yukio Tada

Yasuo Aoki

Shigenori Nakanishi

Mitsuru Sakai

Terumi Hachiya

Naosuke Matsuura

Kenji Yamagata

Jun'ichiro Kita

Hiroshi Fujiwara

Yoshiaki Kuroki

Shinji Takamura

Itsuo Nishioka

Yoichi Nakashima

Yoshio Kaku

Shuichi Ueda

Kayoko Yamano

Takeshi Wakamatsu

Iichiro Horimi

Yasushi Haraguchi

Osami Sakamoto

Koichiro Ueda

Akira Yagi

Koji Waragai

Hideyuki Ozawa

Yutaka Ono

Hideki Kawamura

Masao Maruno

The present invention offers 7-aminoquinolinone derivatives, physiologically acceptable salts thereof, anti-allergic agents having as an active ingredient a 7-aminoquinolinone derivative or physiologically acceptable salt thereof, and 7-nitroquinolinone derivatives, wherein the 7-aminoquinolinone derivative is expressed by the following general formula (I): ##STR1## wherein R.sub.1 is a hydrogen atom or an alkyl group;

Quinolinone derivative and anti-allergic agent with said quinolinone

Compound and use of the same as medicine

A 5-fluorouracil derivative represented by the formula (1): ##STR1## wherein A represents a group represented by ##STR2## wherein R.sup.1 represents a hydrogen atom or OR.sup.5 group, R.sup.2, R.sup.3 and R.sup.5 may be the same or different and each represents a hydrogen atom or a group represented by the following formula (2): ##STR3## wherein R.sup.6 represents an acyl group, R.sup.7 represents a hydrogen atom, a straight or branched alkyl group, a cycloalkyl group, an aralkyl group, a lower alkenyl group or a phenyl group, and n is an integer of 0 to 6,

5-fluorouracil, 2'-deoxy-5-fluorouridine and 1-carbomoyl-5-fluorouracil

Disclosed is a compound represented by Formula (I): ##STR1## wherein Ar.sup.1, Ar.sup.2, n, A, B and Z are as defined in claims. Disclosed are also a process for preparing the compound and pharmaceutical compositions containing the compound. The compound has an antihistamic and antiallergic effect.

Piperdine and piperazine derivatives, and antihistaminic pharmaceutical

This invention provides an amide compound represented by the formula ##STR1## wherein R.sub.1 is vinyl, 2-(methylsulfinyl)ethyl, 2-(methylsulfonyl)ethyl, 2-(2-acetylamino-2-carboxyethylthio)ethyl or 2-[2-(4-amino-4-carboxybutyrylamino)-2-(carboxymethylcarbamoyl)ethylthio]e thyl and R.sub.2 is hydrogen or lower alkyl, process for the preparation thereof, and antiallergic compositions cotaining the amide compound.

Amide compounds

Sulfonium compounds represented by the formula ##STR1## having immunostimulant activity and useful as the active components of drugs and agricultural chemicals.

Sulfonium compounds

This invention provides novel sulfonium compounds, processes for the preparation of the sulfonium compounds, and pharmacological composition containing the sulfonium compound. The compounds of this invention are useful for treating allergy.

Sulfonium compounds, processes for preparing the compounds and

An antiallergic composition comprising, as the effective ingredient, a compound represented by the following general formula ##STR1## wherein R is n-butyl group or n-pentyl group, the compound being preferably supported by a carrier such as sugar, starch, gum arabic or calcium stearate.

Antiallergic compositions

An alkyl-ketohexopyranoside derivative having pharmacological actions such as antiallergic actions, represented by the following general formula ##STR1## wherein R is an alkyl group having at least 3 carbon atoms, the derivatives excluding the D-fructose derivative wherein R is n-propyl group.

Alkyl-ketohexopyranoside derivatives and method of use

Sulfonium compounds represented by the formula ##STR1## have anticancer activity, immunostimulant activity and the like, and useful as the active components of drugs and agricultural chemicals.

The present invention relates to novel cyclohexanecarboxylic acid and its derivatives represented by the general formula: ##STR1## (wherein R.sup.1 is selected from the group consisting of hydrogen or methyl; R.sup.2 is selected from the group consisting of hydroxyl, lower alkoxy with 1-6 carbons or amino acid rest. In case R.sup.1 is hydrogen, however, R.sup.2 means amino acid rest, which of all the compounds of the present invention are entirely novel ones which have never been in any printed publications, possessing a high degree of pharmacological activities such as anti-allergic, anti-inflammatory, anti-ulcerative, antibacterial, anti-thrombotic and liver-function-improving activities, and therefore, these compounds are useful as medicines, and besides, these compounds are surface-active and, therefore, useful as additives for toothpaste and shampoo, as surface active agents for detergents, dispersing agents, emulsifying agents and cosmetics, as anticarious agents, and also in industrial fields the aforesaid compounds are useful as detergents for keeping textiles soft, as additives for lubricating oil, as anti-rust agents, additives for plastics and also as metal-capturing agent, ion-floating agents and emulsifying agents for other industrial purposes).

Novel cyclohexanecarboxylic acid and its derivatives

Growing community of inventors

Gifu, Japan

Akihide Koda