Eisai R&d Management Co., Ltd.

Mercian Corporation

Eisai Company, Limited

Akifumi Okuda

Takashi Nakashima

Satoshi Yamamoto

Tomohiro Sameshima

Naoto Kawamura

Susumu Takeda

Takashi Sakai

Kiyoshi Okamoto

Mitsuo Nagai

Yoshihiko Kotake

Jun Niijima

Toshio Tsuchida

Masashi Yoshida

Kazuyuki Dobashi

Yoshiharu Mizui

Toshimitsu Uenaka

Takao Yamori

Masanori Fujita

Naoki Asai

Motoko Matsufuji

Tomonari Yamada

Keisuke Komeda

Kumiko Kishi

Masao Iwata

Koji Norihisa

Katsura Kaneko

Taira Kato

The present invention provides a novel method of producing the 12-membered ring macrolide compound 11107D having an antitumor activity by biological transformation. Starting material which is the 12-membered ring macrolide compound 11107B represented by the formula (I) is incubated in the presence of a strain belonging to the genus, the genusor the family Micromonosporaceae (for example,sp. AB-1704 strain (FERM BP-8551)), each of which has the ability of transforming the 12-membered ring macrolide compound 11107B into a 11107D substance represented by the formula (II), or a preparation of its cultured myceha and oxygen, and then 11107D substance which is a target material is collected from the treating solution. 

Method of producing macrolide compound

The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution ofsp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it. 

Bioactive substance

The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution ofsp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it

Physiologically active substances

Growing community of inventors

Ibaraki, Japan

Akifumi Okuda