Suntory Holdings Limited

Akifumi Maeda

Norifumi Tateishi

Kayo Saito

Yoshiko Ono

Sumio Asami

Daisuke Takemoto

The present invention relates to a composition containing riboflavin and a sesamin-class compound(s). This composition may incorporate a sesamin-class compound(s) in such an amount that the proportion (weight ratio) of its total quantity to the total quantity of riboflavin taken as unity is no more than 4.5, and it has the advantage that the analgesic and anti-fatigue actions of riboflavin are synergistically improved by ingestion of riboflavin in combination with a sesamin-class compound(s). The composition of the present invention provides compositions, in particular, pharmaceuticals as well as foods and beverages that are safe to humans, animals, etc., and can therefore be ingested for a continued period, and which have far superior effects to those of conventional foods having an analgesic or anti-fatigue action.

Compositions containing riboflavin and sesamin-class compounds

Anti-fatigue agents containing dioxabicyclo[3.3.0]octane derivatives such as sesamin which is an ingredient contained in sesame, as well as pharmaceutical compositions and physiologically functional foods that contain such anti-fatigue agents are disclosed. These compounds can safely be administered to humans and animals alike and hence allow for continued ingestion while proving effective in promoting an improvement of stamina, an increase of body strength, a relief of fatigue, and recovery from fatigue.

Anti-fatigue agent

Disclosed is a composition which is safe for a human body and an animal, can be ingested continuously on a daily basis, has an anti-fatigue activity, and is effective for the prevention or treatment of a disease or condition associated with fatigue. Specifically disclosed is an anti-fatigue agent comprising andrographolide optionally together with an &#x3b1;-lipoic acid as an active ingredient(s). Also disclosed is a novel oral composition comprising andrographolide and an &#x3b1;-lipoic acid. The anti-fatigue agent and the oral composition are useful for the prevention or treatment of chronic fatigue syndrome, overfatigue, physical fatigue, mental fatigue and organ fatigue.

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Osaka, Japan

Akifumi Maeda