Otsuka Pharmaceutical Factory, Inc.

Otsuka Pharmaceutical Company, Limited

Akifumi Hagi

Yasuhide Inoue

Kazuyoshi Miyata

Motoya Kikuchi

Tetsuya Sato

Hiroshi Ishikawa

Hidetsugu Tsubouchi

Takashi Okamura

Kinji Hashimoto

Koushi Iwata

Hitoshi Ohno

Kinue Ohguro

Norihiro Yoshinaga

Yoshihiko Tsuda

Masako Doi

Mari Shiozaki

Yasuhiro Sakai

Shinya Miki

Takuya Nii

Kaoru Imai

Takahiro Tomoyasu

Akiyoshi Kuroda

Seiichirou Kanou

Yoshie Tsubotani

Ryohei Tsubakiyama

Takashi Editaun Gomaihama D-10 Okamura

Kinue Guran Kawauchi Tower 1304 Ohguro

Koushi Sanraunjihaitsu 205 Iwata

An object of the present invention is to provide a composition that can be used as a novel anti-inflammatory agent. An inflammation such as stomatitis, oral mucositis, gingivitis, or pneumonia can be ameliorated and/or prevented by using a composition comprising olanexidine or a pharmacologically acceptable salt thereof. The composition of the present invention preferably further comprises a poloxamer which is a block copolymer consisting of a chain of polyoxypropylene (POP) and two chains of polyoxyethylene (POE) flanking the POP.

Method of treating and/or preventing inflammation by administering olanexidine

It is to provide a disinfectant liquid which enables easy identification of the application sites in preoperative skin disinfection and the like, where the liquid is obtained by coloring an aqueous solution of olanexidine gluconate which is a colorless and transparent liquid. A disinfectant liquid comprises olanexidine gluconate, a coloring agent such as Sunset Yellow FCF, an alkyl dimethylamine oxide such as lauryl dimethylamine oxide, and optionally one or more surfactants other than alkyl dimethylamine oxide such as polyoxyethylene alkyl ether including lauromacrogol and polyoxyethylene polyoxypropylene alkyl ether including polyoxyethylene(20) polyoxypropylene(4) cetyl ether. The disinfectant liquid enables easy identification of the application sites in preoperative skin disinfection and the like.

Skin disinfectant composition

The present invention provides a disinfectant that contains olanexidine in a concentration sufficient to exhibit an effective bactericidal effect, and that has hardly any side effects such as skin irritation. Specifically, the present invention provides a disinfectant containing an aqueous solution that contains olanexidine and at least an equimolar amount of gluconic acid, and substantially contains neither an acid other than gluconic acid nor a salt of the acid other than gluconic acid.

Aqueous solution of olanexidine, method of preparing the aqueous solution, and disinfectant

The present invention provides a phosphonic acid diester compound represented by General Formula wherein R, R, Rand Rare the same or different, and represent hydrogen, halogen, lower alkyl or lower alkoxy; Ris phenyl having on the phenyl ring 1&#x2013;3 substituents selected from the group consisting of lower alkyl, halogen-substituted lower alkyl, lower alkoxy, halogen-substituted lower alkoxy, phenoxy, benzyloxy, hydroxyl, halogen, nitro, lower alkylthio, di(lower alkyl)amino, lower alkanolyamino, pyrrolidinyl and phenyl, or the like, provided that Ris not mono(lower alkoxy)pheny; and Ris lower alkyl;and an ACAT-1 inhibitor containing the compound as an active ingredient.

Phosphonic diester derivatives

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Tokushima, Japan

Akifumi Hagi