Nihon Kohden Corporation

Hitachi, Ltd.

Tokyo Women's Medical University

Akane Suzuki

Takahiro Shioyama

Sunao Takeda

Teruo Okano

Tatsuya Shimizu

Hirotsugu Kubo

Yuji Haraguchi

Yo Kato

Nae Hinata

Takahiro Fujishiro

Kenichi Nomura

Chinatsu Sato

Yoshitaka Amano

Provided is a cell isolation instrument capable of smoothly performing a plurality of steps associated with isolation of cells, including gripping of a biological tissue, transferring of the biological tissue, and isolating of the biological tissue. A container has an opening. A sealing member seals the opening. A pair of pinching parts is connected to the sealing member, and the pair of pinching parts opens or closes by being pressed.

Cell isolation instrument

An apparatus and a method for diagnosing a tumor are provided. A histogram generating section generates a histogram from a result of a measurement of fluorescence intensity of a suspension produced from a target sample. The histogram indicates a relation between the fluorescence intensity and the number of cells. A determination section detects an S phase fluorescence intensity range corresponding to S phase cells based on the fluorescence intensity corresponding to a peak of the number of cells in the histogram, detects an abnormal fluorescence intensity range corresponding to tumor cells, based on a change in the number of cells in the S phase fluorescence intensity range, and performs a diagnosis of a tumor in the target sample based on an index of the number of cells in a range defined by excluding the abnormal fluorescence intensity range from the S phase fluorescence intensity range.

Method and apparatus for diagnosing a tumor using a histogram and excluding abnormal fluorescence corresponding to DNA aneuploidy

A cell analyzer includes: a measuring portion which measures cells that are nuclear stained; a displaying portion which displays a histogram of a fluorescence intensity by using a result of the measurement by the measuring portion; and a determining unit which obtains a number of strong-area cells that are distributed in an area where the fluorescence intensity is stronger than normal cells, and which determines a malignancy grade of cancer based on the number of strong-area cells and the histogram.

Cell analyzer and cell analyzation method

A method of analyzing cells, the method comprising: measuring a number of cells which are nuclear stained, in a to-be-determined tissue, and acquiring a histogram showing a fluorescence intensity based on a result of the measurement; analyzing the histogram, and acquiring data of predetermined parameters; comparing the data of the parameters with first thresholds predetermined for the parameters, to perform a first cancer determination for each of the parameters on the to-be-determined tissue; performing a scoring process for each of the parameters, on a result of the first cancer determination for each of the parameters, to calculate scores of the parameters; and combining the scores of the parameters with one another, thereby performing a second cancer determination on the to-be-determined tissue.

Method and apparatus for analyzing cells

A cell analyzing apparatus includes: a histogram acquirer which is configured to perform measurement of a number of nuclear stained cells, and which, by using a result of the measurement, is configured to acquire a histogram indicating a fluorescence intensity; and an analysis controller which is configured to apply frequency analysis on data of the histogram acquired by the histogram acquirer, and which is configured to determine existence/nonexistence of cancer cells based on a result of the frequency analysis.

Cell analyzing apparatus and cell analyzing method

A cell analyzing apparatus includes: a first histogram acquiring section which is configured to acquire a first histogram of fluorescence intensities by using a result of a measurement of a number of nuclear stained cells; a second histogram acquiring section which is configured to acquire a second histogram that is normalized based on a fluorescence intensity value indicating a maximum value of the first histogram; a determining section which is configured to determine whether cancer cells exist or not, based on one of the first histogram and the second histogram; and an outputting section which is configured to output a result of the determination performed by the determining section.

On the basis of revocation information of a certificate, information of a certification authority and of the certificate issued by the certification authority from a terminal device, and information of a cryptographic algorithm, validity of the certificate from the terminal device is determined. If the certificate is valid, a validation result treating the certificate as valid is created, and using information of the cryptographic algorithm from the terminal device and information of the cryptographic algorithm used for the signature of the certification authority which has been imparted to the revocation information of the certificate, a selection list of cryptographic algorithms used for the response signature to impart to the verification result of the certificate is created to determine the cryptographic algorithm used for the response signature to impart the verification result of the certificate on the basis of the created list and the cryptographic algorithms capable of being accommodated by the verification server.

Determination method for cryptographic algorithm used for signature, validation server and program

A pipette member to be attachable to a container capable of accommodating a tissue and a liquid, is used for isolating cells from the tissue by stirring, and includes: a cylinder member which includes a first opening that is to be accommodated in the container, and a second opening that is to be connected to a cell isolation apparatus, and in which a passage for communicating the first opening with the second opening is defined; and a filter member which is disposed inside the cylinder member, and which separates the passage into a first part that includes the first opening, and a second part that includes the second opening.

Pipette member and cell isolation instrument

A cell isolation apparatus includes: a chamber body which includes a chamber into which tissue is to be introduced; an isolation member which is moved in the chamber and which is to collide with the tissue to isolate a cell; and a controlling portion which controls an operation of the isolation member in the chamber body.

Cell isolation apparatus

A cell isolation instrument includes: a first container which has an opening in an upper portion; a filtration member which defines at least a part of a lower portion of the first container; an isolation member which is movably housed in the first container to collide with a tissue, thereby isolating cells; and a second container which houses the first container in a manner that the first container can be taken out.

A cell isolation apparatus includes: a cylinder member that is inserted into a container into which a reagent is to be introduced; a net which is stretched over the cylinder member; a tissue acquiring unit that is projected from the cylinder member; and a bottom lid portion that is configured by a bottomed pipe in which a first hole that communicates an interior with an exterior is formed, and that is fitted to a bottom portion of the cylinder member in a state where the net and the tissue acquiring unit are accommodated.

Growing community of inventors

Tokyo, Japan

Akane Suzuki