Nof Corporation

Akane Katori

Nobuyuki Sakamoto

Takashi Sasaki

Hirotaka Suzuki

Yosuke Matsuoka

Norio Iwakiri

Tomozumi Noda

Masaru Matsuda

Shu Takashima

Ryuya Gotanda

Provided is a monomer suitable for application to an ophthalmic device, the monomer showing high surface hydrophilicity, a high oxygen transmissibility, and appropriate mechanical strength when copolymerized with a polymerizable monomer, such as a hydrophilic monomer. It has been recognized that a phosphorylcholine group-containing polysiloxane monomer can solve the problems.

Phosphorylcholine group-containing polysiloxane monomer

A compound is provided which is effectively adsorbed to a substrate surface, such as an immune reaction vessel, has extremely high protein adsorption inhibitory effect that inhibits non-specific adsorption of protein or the like, and has excellent washability to retain the inhibitory effect before and after washing operation of the substrate. Also provided are a protein adsorption inhibitor using the compound, a phosphorylcholine-modified substrate, and a method for inhibiting protein adsorption. The compound is a phosphorylcholine group-containing polyethylene glycol derivative represented by formula (1). The method for inhibiting protein adsorption of the present invention includes the step of forming an adsorbed layer of the derivative on a substrate surface. 

Poly(ethylene glycol) derivative and protein-adsorption inhibitor

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Kanagawa, Japan

Akane Katori