Rutgers, the State University of New Jersey

Taxis Pharmaceuticals, Inc.

University of Medicine and Dentistry of New Jersey

Ajit S Parhi

Edmond Joseph LaVoie

Daniel S Pilch

Malvika Kaul

Yongzheng Zhang

Kalyan Das

Joseph David Bauman

Eddy Arnold

Hye Yeon Sagong

Gifty A Blankson

Disha Patel

Suyambu Kesava Vijayan

Yi Yuan

Yangsheng Sun

Ravi Ponnaiah

Anil Kumar Soni

Pullarao Seelam

John E Kerrigan

Thrisulapani Korrakuti

Sanjeevani Ghone

Fu-An Kang

Nareshkumar Jain

Siva Rami Reddy Athunuri

Xiao Chen

Cody Kelley

Dishaben V Patel

Liping Wang

Disclosed herein are compounds of formula (I): and salts thereof. Also disclosed are compositions comprising compounds of formula I and compounds of formula I for use in treating or preventing bacterial infections.

Indole derivatives as efflux pump inhibitors

Disclosed herein are compounds of formula I and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.

Bacterial efflux pump inhibitors

Disclosed herein are compounds of formula I: or a salt thereof and compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods for treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I or a pharmaceutically acceptable salt thereof, alone or in combination with a bacterial efflux pump inhibitor. 

Therapeutic compounds and methods to treat infection

Disclosed herein are compounds of formula I and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I. 

The invention provides synthetic methods and synthetic intermediates that are useful for preparing the antibacterial compound: 

Antimicrobial agents

Provided herein are compounds of formula (I): and salts thereof. Also provided are pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula (I), and therapeutic methods for treating diseases such as cancer, a bacterial infection or a fungal infection using compounds of formula (I). 

Topoisomerase poisons

Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I. 

The invention provides synthetic intermediates and synthetic processes that are useful for preparing the antibacterial agent TXA709: 

Synthetic processes and synthetic intermediates

The invention provides compounds of formula (I): wherein R-R, n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.

Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising of compounds of formula I and methods using compounds of formula I.

The invention provides compounds of formula I: and salts and prodrugs thereof wherein R, Xand Xhave any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties.

Therapeutic hydroxypyridinones, hydroxypyrimidinones and hydroxypyridazinones

The invention provides methods of treating a bacterial infection in a mammal comprising administering to the mammal a substituted bicyclic heteroaromatic ring compound of formula I: wherein two of Xto Xare N and the remaining of Xto Xare CH; or a pharmaceutically acceptable salt thereof, as well as novel compounds of formula I and salts thereof and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. 

The invention provides compounds of formula (I) and salts thereof wherein R-Rhave any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties. 

Growing community of inventors

Monmouth Junction, NJ, United States of America

Ajit S Parhi