Rutgers, The State University of New Jersey

Taxis Pharmaceuticals, Inc.

Ajit K Parhi

Edmond Joseph LaVoie

Daniel S Pilch

Malvika Kaul

Ravi Ponnaiah

Anil Kumar Soni

Thrisulapani Korrakuti

Pullarao Seelam

Yongzheng Zhang

Hye Yeon Sagong

Siva Rami Reddy Athunuri

Sanjeevani Ghone

Fu-An Kang

Nareshkumar Jain

Sudhakar Sunkari

Savi Rami Reddy Athunuri

The invention provides synthetic intermediates and synthetic processes that are useful for preparing the antibacterial agent TXA709:

Synthetic processes and synthetic intermediates

Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.

Bacterial efflux pump inhibitors

Disclosed herein are compounds of formula (I), or a salt thereof and compositions comprising compounds of formula I that exhibit antibacterial activities, when tested alone and/or in combination with a bacterial efflux pump inhibitor. Also disclosed are methods of treating or preventing a bacterial infection in an animal comprising administering to the animal a compound of formula I alone or in combination with the administration of a bacterial efflux pump inhibitor.

Therapeutic compounds and methods to treat infection

The invention provides synthetic processes and synthetic intermediates that can be used to prepare a compound of formula (I): or a salt thereof.

Synthetic processes and intermediates

Growing community of inventors

Monmouth Junction, NJ, United States of America

Ajit K Parhi