Lupin Laboratories Limited

Ajay Singh Rawat

Mukesh Jagannath Wani

Ashoke Kumar

Narendra Sriram Joshi

Pravin Sahadev Thombre

Dharmendra Singh

N-7 isomer of the formula ##STR1## is converted into a N-9 isomer of the formula ##STR2## by heating a suspension of the N-7 isomer in an alkylating agent of the formula ##STR3##

Regiospecific process for synthesis of acyclic nucleosides

This invention relates to an improved regiospecific process for the synthesis of acyclic nucleosides such as, acyclovir and ganciclovir, anti-viral compounds especially effective against herpes virus, and intermediates thereof starting from dyacylguanine and an alkylating agent, selected from 2-oxa-1,4-butanediol diacetate (OBDDA), 1,4-diacetoxy-3-acetoxymethyl-2-oxa-butane, 1,4-dibenzyloxy-3-acetoxymethyl-2-oxabutane. The reaction is carried out in the absence of an acid catalyst and a solvent.

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Mandideep, India

Ajay Singh Rawat