Lupin, Inc.

Ajay Ramchandra Tilekar

Venkata Poornapragnacharyulu Palle

Rajender Kumar Kamboj

Neelima Sinha

Navnath Popat Karche

Anil Kashiram Hajare

Gourhari Jana

Sanjay Pralhad Kurhade

Sachchidanand Sachchidanand

Shridhar Keshav Adurkar

Baban Rupaji Thube

Bikramjit Singh Lairikyengbam

Firoj Aftab Raje

Disclosed are an alpha 7 nAChR receptor modulator compound, 4-(5-(4-chlorophenyl)-2-(2-cyclopropylacetyl)-1,4-dimethyl-1H-pyrrol-3-yljbenzenesulfonamide, its tautomeric form, its pharmaceutically acceptable salts, pharmaceutical compositions comprising the compound or a salt thereof, and a method of treating various diseases, disorders or conditions, for example, Alzheimer's disease, mild cognitive impairment, senile dementia, vascular dementia, dementia of Parkinson's disease, and attention deficit disorder.

4-(5-(4-chlorophenyl)-2-(2-cyclopropylacetyl)-1,4-dimethyl-1H-pyrrol-3-yl)benzenesulfonamide as alpha 7 nAChR modulator

Disclosed is a compound of formula I: wherein Z, m and R-Rare as described herein, as a modulator of nicotinic acetylcholine receptors particularly the &#x3b1;7 subtype, in a subject in need thereof, as well as analogues, prodrugs, isotopically substituted analogs, metabolites, pharmaceutically acceptable salts, polymorphs, solvates, isomers, clathrates, and co-crystal thereof, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds and analogues. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like.

Heteroaryl derivatives as alpha7 nAChR modulators

Disclosed is a compound of formula (I) wherein Y, Ring D, m and R-Rare as described herein, as a modulator of nicotinic acetylcholine receptors particularly the &#x3b1;7 subtype, in a subject in need thereof, as well as pharmaceutically acceptable salts, polymorphs, solvates, and isomers thereofs, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like. 

Thiazole derivatives as alpha 7 nAChR modulators

Disclosed is a compound of formula (I) wherein 'a' and R-Rare as described herein, as a modulator of nicotinic acetylcholine receptors particularly the &#x3b1;7 subtype, in a subject in need thereof, as well as analogs, prodrugs, isotopically substituted analogs, metabolites, pharmaceutically acceptable salts, polymorphs, solvates, isomers, clathrates, and co-crystal thereofs, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds and analogs. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like. 

Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease

Disclosed is a compound of formula (I), wherein Z, m and R-Rare as described herein, as a modulator of nicotinic acetylcholine receptors particularly the &#x3b1;7 subtype, in a subject in need thereof, as well as analogs, prodrugs, isotopically substituted analogs, metabolites, pharmaceutically acceptable salts, polymorphs, solvates, isomers, clathrates, and co-crystal thereof, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds and analogs. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like. 

Growing community of inventors

Pune, India

Ajay Ramchandra Tilekar