University of Central Florida Research Foundation Inc

Ajay Karakoti

Sudipta Seal

David Reid

Larry L Hench

Suresh Babu Krishna Moorthy

Vijayalakshmi Shridhar

Peter Brenneisen

Shailendra Giri

Nanoparticles disclosed in the invention comprise a dextran-coated crystalline structure of cerium oxide wherein tetravalent Cepredominates over trivalent Ceand wherein said nanoparticles have a diameter of approximately from 3 to 5 nm. The nanoparticles exhibit both superoxide dismutase activity and catalase activity in an environment having a substantially neutral or acidic pH. The nanoparticles may be used to make and may be contained in a medication. The subject nanoparticles are useful in a method of promoting a cytotoxic anti-invasive effect on squamous tumor cells and inhibit tumor invasiveness.

Redox active cerium oxide nanoparticles and associated methods

Processes and methods of making and preparing, compositions and structural products therefrom are provided, whereby the surface area of alumino-silicate based powders is greatly increased and rendered chemically active so that when the functionalized powders are mixed with water poly-condensation reactions occur between the surfaces binding the powders together to form a structural material with negligible emission of carbon compounds. In another embodiment, the surface functionalized powders can be mixed with an additive; a dry aggregate, such as sand and water to make a slurry that can be poured or cast into any desired shape and rapidly cured to a hardened shape suitable for use as a structural material with the mechanical strength equivalent to Portland-cement based concrete products. In additional embodiments, the alumino-silicate based powders are nano-functionalized and foam functionalized to provide light weight and structurally strong materials that can also be used in combination with or as replacement for Portland-cement.

Structural materials with nearly zero carbon emissions

The invention provides a method of treating ovarian cancer in a mammal, the method inhibits angiogenesis associated with the cancer and comprises the parenteral administration to the mammal of an effective amount of cerium oxide nanoparticles having a predominance of Ce.

Inhibition of angiogenesis associated with ovarian cancer by nanoparticles of cerium oxide

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Richland, WA, United States of America

Ajay Karakoti