Queen's University at Kingston

Neurochem (international) Limited

The Sir Mortimer B. Davis-jewish General Hospital

Osta Biotechnologies

Bellus Health (international) Limited

Ajay Gupta

Walter A Szarek

Xianqi Kong

Donald F Weaver

David Migneault

Hyman M Schipper

Moulay Alaoui-Jamali

Kanji Nakatsu

Jason Z Vlahakis

Francine Gervais

Robert Chalifour

Disclosed are compounds of the general formula (I): compositions comprising an effective amount of said compounds either alone or in combination with other chemotherapeutic agents, and methods useful for treating or preventing cancer and for inhibiting tumor tissue growth. These compounds attenuate the oxidative damage associated with increased heme-oxygenase activity and can reduce cell proliferation in transformed cells. In addition, the described compounds and compositions are useful as neuroprotectants and for treating or preventing neurodegenerative disorders and other diseases of the central nervous system.

Substituted imidazole derivatives and methods of use thereof for treating cancer

Disclosed in certain embodiments is a method of treating and/or mitigating prostate cancer, ovarian cancer, melanoma, colorectal cancer, breast cancer or lung cancer, comprising administering to an individual in need thereof a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of formula (I): 

Methods of treating cancer with imidazolyl compounds

Methods and compositions which are useful in the treatment of amyloidosis. In particular, methods and compositions are provided for inhibiting, preventing and treating amyloid deposition, e.g., in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. The methods of the invention involve administering to a subject a therapeutic compound which inhibits IAPP-associated amyloid deposits. Accordingly, the compositions and methods of the invention are useful for inhibiting IAPP-associated amyloidosis in disorders in which such amyloid deposition occurs, such as diabetes.

Methods and compounds for inhibiting amyloid deposits

The present invention relates to antifibrillogenic agents for inhibiting amyloidosis and/or for cytoprotection for the treatment amyloidosis disorders. These agents include peptides, isomers thereof and peptidomimetic compounds thereof. These agents comprise peptide having a sequence identified from the glycosaminoglycan (GAG) binding region and the prot&#x2014;prot interaction region of the amylo protein. The peptide has at least one [D] amino acid isomer substitution. The invention also relates to the peptide bound to a label for vivo imaging of amyloid deposits.

Stereoselective antifibrillogenic peptides and peptidomimetics thereof

Growing community of inventors

Dollard-des-Ormeaux, Canada

Ajay Gupta