Edwards Lifesciences Corporation

Other

Ajay Chadha

Son V Nguyen

Kevin D Rupp

Jeff Lindstrom

Tamir S Levi

Boaz Manash

Elena Sherman

Darshin S Patel

Ron Sharoni

Khen Perlmutter

Waina Michelle Chu

Sandip Vasant Pawar

Evan T Schwartz

Oren H Wintner

Chambory Chhe

Arvin T Chang

Sam Sok

Sara Tzadok

Amanda Kristine Anderson White

Amanda K Anderson

Sara Haivatov

A prosthetic heart valve has a frame including a plurality of strut members, the frame being radially expandable and collapsible between a collapsed state and an expanded state, the frame having an inflow end and an outflow end and defining a longitudinal axis. A leaflet structure is situated at least partially within the frame. A covering is disposed around an exterior of the frame and includes a cushioning layer, a first strip of material coupled to the cushioning layer and folded to encapsulate apices of the strut members of the inflow end of the frame, and a second strip of material coupled to the cushioning layer and folded to encapsulate apices of the strut members of the outflow end of the frame. The cushioning layer includes texturized filaments that provide compressible volume and a plush surface to the cushioning layer when the frame is in the expanded state.

Covered prosthetic heart valve

Embodiments of a radially collapsible and expandable prosthetic heart valve and method for crimping the prosthetic heart valve are disclosed. A method of radially compressing a prosthetic valve can include partially inserting the valve while in a radially expanded configuration into a crimping device comprising crimper jaws, wherein a portion of the valve comprising an outer skirt extends outside of the crimper jaws. The method can further include crimping the valve to a first partially collapsed configuration, further inserting the valve into the crimping device, such that the outer skirt is between the crimper jaws, and crimping the valve to a second partially collapsed configuration, wherein a diameter of the valve is smaller in the second partially collapsed configuration than in the first partially collapsed configuration.

Prosthetic heart valve

A prosthetic heart valve has a frame including a plurality of strut members, an inflow end, and an outflow end. A leaflet structure is situated at least partially within the frame, and a covering is disposed around an exterior of the frame. The covering includes a cushioning layer, and a first strip member folded over an inflow circumferential edge portion of the cushioning layer to form a first protective portion. A second strip member is folded over an outflow circumferential edge portion of the cushioning layer to form a second protective portion. The first strip member and the second strip member are spaced apart from each other along a longitudinal axis of the prosthetic heart valve.

A docking device includes a hollow cylindrical body portion having an internal surface and an outer surface. The hollow cylindrical body portion is formed of a three-dimensional (3D) woven fabric comprising a plurality of different types of fibers.

Three-dimensional woven fabric implant devices

A delivery cylinder for a prosthetic implant can include a first tubular portion and a second tubular portion. The second tubular portion has a plurality of strut members coupled to the first tubular portion that define a volume for containing the prosthetic implant in a radially compressed state. The strut members can include respective flex regions configured such that application of force to the strut members causes deformation of the flex regions and corresponding radially inward or outward movement of the strut members relative to a longitudinal axis of the delivery cylinder between an expanded configuration and a contracted configuration.

Delivery cylinder for prosthetic implant

A prosthetic heart valve includes a frame having a plurality of strut members, an inflow end, and an outflow end. The prosthetic heart valve further includes a leaflet structure situated at least partially within the frame, and a covering disposed around the frame. The covering has a first layer and a second layer, wherein the second layer has a plush surface. The first layer is folded over a circumferential edge portion of the second layer to form a protective portion that extends beyond the strut members in a direction along a longitudinal axis of the prosthetic heart valve.

Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. The prosthetic valve can comprise an annular frame, leaflets, an inner skirt, and an outer skirt. The outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack that buckles outward radially when the valve is in the expanded configuration and which lies flat when the valve is in the collapsed configuration. In some embodiments, the outer skirt is stiffer in the axial direction of the valve than in the circumferential direction of the valve. In additional embodiments, the outer skirt comprises a self-expandable fabric comprising fibers made of a shape memory material having a shape memory set to enhance the radially outward buckling of the outer skirt. Methods of crimping such valves to a collapsed or partially collapsed configuration are also disclosed.

A textured fabric for an implantable bioprosthesis is provided. The textured fabric can include a woven base layer and a plurality of loops projecting from the woven base layer. The plurality of loops are formed from a composite core-sheath yarn. The core can be made of a material that is different from the sheath. The core material can be selected to impart strength and resiliency to bending and the sheath material can be selected to impart a larger surface area or texture that facilitates cellular or tissue in-growth.

Textured woven fabric for use in implantable bioprostheses

A docking device for a bioprosthesis is disclosed that can change shape and recover after a deforming stress is removed, that adjusts to surrounding conditions to accommodate different complex anatomic geometries, and that mitigates leakage around the bioprosthesis. The docking device can include a 3D woven fabric forming an internal surface, an outer surface, and a thickness therebetween. A filler can be coupled to the outer surface. A method for making a docking device is also provided. The method includes weaving a 3D woven fabric by interlacing a shape memory material, a low-melt thermoplastic polymer or resin having a melting point, and a high-tenacity biocompatible material; and pressing and heating the 3D woven fabric over a shape-setting mold at temperatures greater than the melting point of the low-melt thermoplastic polymer or resin.

Docking device made with 3D woven fabric

A dispensing formulation for use in combination with an indirect heating source. In the preferred embodiment the dispensing formulation includes an additive such as a fragrance or a therapeutic compound, a hydrocarbon oil, having a flash point below 400&#xb0; F. (generally between 330-400&#xb0; F., most preferably between 330-355&#xb0; F.) and a mixture of commercially available triblock polymers, such as Kraton&#xae; and Septon&#xae;.

Dispensing formulation

A display device for creating a backlit effect on a display article&#x2014;such as a photograph&#x2014;with a candle. The display device includes a candle container and a display panel attached to the wall of the candle container by a stand-off. The wall of the candle, display panel, and stand-off together form a pocket for receiving a sleeve which receives a display article. Both the display panel, inside wall and sleeve allow the light of the candle to transmit through the display device and create a backlit effect on the display article that is viewable through the display panel.

Display device for creating a backlit effect on a display article

A process for adding objects to a candle. Methods are disclosed for adding an object before the fuel has assumed its final state and after the fuel has assumed its final state. Several related approaches for introducing the object are disclosed, including making an incision to insert the object, retracting the fuel away from its container in order to slip the object in between the fuel and the container, and creating a melted region in the fuel which will allow the object's insertion. Once the object is in place, the fuel is locally heated above its melting temperature in order to reflow the fuel around the object. The candle is then cooled so that the fuel transitions back into its normal state.

Growing community of inventors

Irvine, CA, United States of America

Ajay Chadha