Universidad Del País Vasco

Dominion Pharmakine S.l

Ikerchem, S.l.

Ikerschem, S.l.

Universidad Del Pais Vasco-euskal Herriko Unibertsitatea (upv-ehu) Fundacion Centro Nacional De Investigaciones Oncologicas Carlos III (cnio)

Universidad Del País Vasco/euskal Herriko Unibertsitatea

Aizpea Zubia Olascoaga

Miren Lorea Mendoza Arteche

Fernando Pedro Cossio Mora

Fernando Vidal Vanaclocha

Eneko Aldaba Arévalo

Fernando Pedro Cossio

Yosu Ion Vara Salazar

Silvia Vivanco Amato

Natalia Gallot Escobal

María Valcárcel Cuesta

Yosu Ion Vara Zalazar

Yosu Ion Vara Salazr

Dorleta Otaegui Ansa

Manel Esteller Badosa

Eider San Sebastian Larzabal

Jose Javier Lopez Pestana

Miren Sorne Solaun Aguirre

Clarisa Salado Pogonza

Eneko Aldaba Arevalo

María Del Carmen Masdeu Margalef

Eider Ion San Sebastián Larzabal

Yosu Vara Salazar

Fernando Pedro Cossío Mora

Eider San Sebastián Larzabal

Leire Lidia Arias Echeverría

Maria Del Masdeu Margalef

The present invention refers to compounds of formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and use thereof for the treatment and/or chemoprevention of cancer, aging related diseases or processes, diabetes and neurodegenerative diseases.

Polysubstituted benzofurans and medicinal applications thereof

The present invention refers to compounds derived from trisubstituted 1H-pyrrole rings and aromatic rings, which have the following formula (I): wherein:

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This invention is related to new nitrogenated trans-stilbene compounds, more specifically, imine, pyrrole and indole derivatives, with procedures for the preparation and use thereof as pharmaceutical compositions for the treatment and/or chemoprevention of those mammalian diseases such as cancer, fibrosclerosis and acute/chronic inflammation, graft-versus-host reaction, ischemic-reperfusion tissue injury in stroke and heart attack, neurodegeneration, and during organ transplantation, whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable oxidative stress, angiogenic and proliferative responses.

Nitrogenated trans-stilbene analogs, method for the obtention and medical applications thereof

The invention relates to the treatment of disorders or diseases mediated by LFA-1/ICAM-1 molecular interaction. This is based on the use of novel chemical compounds capable of inhibiting said interaction, and more particularly, to pharmaceutical compositions containing these compounds.

Inhibitors of the LFA-1/ICAM-1 interaction and uses thereof

The invention describes new compounds derived from formula I pyrroles, methods for obtaining them and their application as drugs in pharmaceutical compositions for the treatment of cancer due to their inhibitory activity on certain histone deacetylases.

Pyrrolic derivatives with histone deacetylase inhibitory activity

This invention relates to nitroproline derivative compounds and procedures for their preparation and the preparation of pharmaceutical compositions containing the compounds. The invention also relates to the administration of compounds of the invention as agents for the treatment of mammalian diseases whose pathogenic and pathophysiological mechanisms depend on or are significantly contributed by undesirable cellular and molecular activities or responses induced by integrin-dependent molecular interactions.

Derivatives of nitroproline compounds, processes of manufacture and uses in the treatment of integrin mediated disorders

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Leioa, Spain

Aizpea Zubia Olascoaga