Shenyang Sinochem Agrochemicals R&d Co., Ltd.

Shenyang Research Institute of Chemical Industry

Sinochem Corporation

Jiangsu Yangnong Chemical Co., Ltd.

Aiying Guan

Changling Liu

Zhinian Li

Jie Lan

Baoshan Chai

Xufeng Sun

Miao Li

Junfeng Wang

Qin Sun

Lizeng Wang

Jinbo Zhang

Hong Zhang

Bin Wang

Yuquan Song

Huichao Li

Cong Feng

Lanhui Ren

Sen Ma

Minna Zhu

Lin Li

Mingxing Zhang

Chunqing Hou

Zhonggang Shan

Jie Zhao

Shaowu Liu

Lanfeng Ban

Qiao Wu

Xiuhui Chang

Guang Huang

Jizhong Zhou

Keke Li

Shulin Hao

Xiaoli Xia

Jinlong Yang

Xiaoping Yang

Fan Yang

Wei Chen

Yinping Zhou

Xuanming Chen

Lijun Ru

Weijing Ren

Airu Jiang

Ying Xu

Yonggang Jia

Zhengming Li

Leichuan Xu

Jinqiang Sun

Enming Wu

Fuqiang Yu

Chunrui Yu

Liping Bai

Youren Xue

Yanming Ye

A method for preparing an isoxazoline-containing uracil compound involves methylation. An isoxazoline-containing uracil compound shown by formula I is prepared by a methylation reaction between a compound shown by formula II and methyl chloride in a closed container in the presence of alkali, a catalyst and an organic solvent; and a reaction equation is as follows:

Method for preparing isoxazoline-containing uracil compound through methylation

The present invention discloses a substituted pyrimidine compound. The structure is shown in general formula I. The definition of each substituent in the formula is described in the description. The compound of the present invention has broad-spectrum fungicidal, insecticidal and acaricidal activity, and has excellent control effects on cucumber downy mildew, powdery mildew, corn rust, anthrax, rice blast, aphids,and the like. 

Substituted pyrimidine compound and preparation method and use thereof

Disclosed are substituted pyrazole compounds containing pyrimidinyl as shown in Formula I: The definitions of each of the substituents can be seen in the description. The compounds of present invention have a good spectrum of bactericidal, insecticidal and acaricidal activity, and have good control effect on downy mildew of cucumber, powdery mildew of wheat, corn rust, rice blast, cucumber anthracnosis and the like. The compounds of present invention also show good insecticidal activity.

Substituted pyrazole compounds containing pyrimidine and preparation method and use thereof

Disclosed are applications of substituent benzyloxy group containing ether compounds represented by general formula I for preparing antitumor drugs.  The definition of the substituent groups in the formula I are provided in the specification. The compounds having general formula I have desirable antitumor activity, particularly, and have excellent activity against leukemia strain HL-60, lung cancer A549, H157, H460, H520, bladder cancer T24, J82, prostate cancer LNCap, PC-3, rectal cancer HCT8, HCT116, RkO and the like.

Applications of substituent benzyloxy group containing ether compounds for preparing antitumor drugs

Disclosed is a substituted pyrimidine compound having a structure as represented by formula PY.  See the description for the definition of each substituent in the formula. The compound of the present invention provides broad-spectrum bactericidal, pesticidal, and acaricidal activities, provides great control effects against plant diseases such as cucumber downy mildew, corn rust, wheat powdery mildew, rice blast, and cucumber gray mold, specifically provides improved control effects against cucumber downy mildew, corn rust, wheat powdery mildew, and rice blast, provides great control effects against aphid, carmine spider mite, diamondback moth, and armyworm, and acquires great effects at a minimal dosage. The compound of the present invention also provides characteristics such as a simplified preparation method.

Substituted pyrimidine compound and uses thereof

Disclosed are pyrazolyl pyrimidinamine compounds with structures as shown in Formula I:  The definitions of each of the substituents can be seen in the description. The compounds of present invention have a broad spectrum of bactericidal, insecticidal and acaricidal activity, and have good control effect on downy mildew of cucumber, powdery mildew of wheat, corn rust, anthracnosis of cucumber and the like, and especially have better control effect on downy mildew of cucumber, powdery mildew of wheat and anthracnosis of cucumber. The compounds of present invention also show good insecticidal activity, part of the compounds, at very low doses, have excellent control effect on diseases caused by, armyworm,etc.

Pyrazolyl pyrimidinamine compound and application thereof

The invention discloses a homopiperony lamine compound which has a structural general formula I as follows as shown in the specification:  The compound shown as the general formula I has broad-spectrum bactericidal and insecticidal activity in the field of agriculture. The compound shown as the general formula I has a good prevention effect on various germs such as cucumber downy mildew, wheat powdery mildew,, rice blast and cucumber gray mold, and particularly, still has the good prevention and control effect on the cucumber downy mildew, theand the wheat powdery mildew at a lower dosage. At the same time, a part of compound has better insecticidal activity, and can be used for preventing and controlling various insect pests such as diamondback moths,, armyworms andboisdu.

Substituted pyrimidines as pharmaceuticals and insecticides

The invention relates to substituted diphenylamine compounds using as antitumor agents. The structure of the compounds is represented as the general formula (I):  The groups are as defined as specification. The compound represented by formula (I) showed potent antitumor activity, especially to cure or alleviate the cancer causing by cancer cells of human tissue or organ. The preferred cancers are: colon cancer, liver cancer, lymph cancer, lung cancer, esophageal cancer, breast cancer, central nervous system cancer, melanoma, ovarian cancer, cervical cancer, renal cancer, leukemia, prostatic cancer, pancreatic cancer, bladder cancer, rectal cancer, osteosarcoma, nasopharynx cancer or stomach cancer.

Substitute diphenylamine compounds use thereof as antitumor agents

Disclosed is a substituted cyanoaniline compound or a salt thereof, wherein the compound has a structure represented by General Formula I. The compound of General Formula I has broad-spectrum fungicidal activity in the field of agriculture and effectively prevents against a variety of pathogens such as cucumber downy mildew, wheat powdery mildew, maize rust disease, rice blast and cucumber gray mold. In particular, even at a low dose, the compound effectively prevents and treats rice blast, cucumber gray mold, maize rust disease and cucumber downy mildew. Moreover, the raw materials for preparing the compounds are widely available and the synthesis method therefor is simple and convenient.

Substituted cyanoaniline compounds, preparation and use thereof

The invention relates to fungicide and insecticide, especifically to the substituted azole compounds and its preparation method and use thereof. The azole compounds of the invention having general formula (I): The compounds of present invention, having broad spectrum fungicidal activity, applied for controlling various disease in plants. For example they have good activity against the diseases such as cucumber downy mildew, cucumber grey mold, cucumber powdery mildew, tomato early blight, tomato late blight, phytophthora blight of pepper, grape downy mildew, grape white rot, apple ring rot, apple alternaria leaf spot, rice sheath blight, rice blast, wheat leaf rust, wheat leaf blotch, wheat powdery mildew, rapesclerotiniose, corn southern leaf blight. Some compounds have good insecticidal or acaricidal activity and can be used to control insects and acacids of various crops. For example they are used to control army worm, diamond backmoth and aphid, and culex mosquito.

Substituted azole compounds and its preparation and use thereof

The invention relates to pesticide and bactericide, specifically to the benzopyrone compounds and its preparation method and use thereof. The benzopyrone compounds of the invention having general formula (I): The present invention, having good pesticide activity and broad bactericide activity, applied for controlling various pests in plants such as army worm, diamond backmoth and aphid, carmine spider mite, two-spotted spider mite, ladybeetle, mites and mosquito larvae. Various disease in plants can be controlled by the invention and that of grape downy mildew, rice sheath and culm blight, rice blast, tomato early blight, tomato late blight, wheat leaf rust, wheat leaf blotch, wheat powdery mildew, cucumber powdery mildew, cucumber downy mildew, cucumber grey mold and so on.

Benzopyrone compounds, preparation method and use thereof

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Liaoning, China

Aiying Guan