Uti Limited Partnership

Aixia Wang

Chang-Chun Ling

Ping Zhang

Lina Cui

Ramprasad Ghosh

The present application provides an amphiphilic cyclodextrin-based compound of the formula I: R-G-D-A (I) wherein R is one or more hydrophilic groups; G is one or more linkers; D is a cyclodextrin, and A is one or more aliphatic groups. In certain embodiments, the hydrophilic group is a sugar such as lactose, the linker comprises &#x2014;(CHR'CHO)&#x2014; where R&#x2032; is H or is an alkyl group substituted with &#x2014;(CHR&#x2032;CHO)&#x2014; where n is 1 to 20, typically n=4; the cyclodextrin is a &#x3b2;-cyclodextrin comprising 7 subunits, and the aliphatic groups are Calkyl groups. The compound can be used to enhance water solubility, bioavailability, cellular uptakes of active ingredients used in medicines, cosmetics and foods and other products, for detection, removal and immobilization of pathogenic organisms, toxins, and autoantibodies, and biomarkers on solid matrix, or for molecular biological techniques, such as ELISA, for example.

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Calgary, Canada

Aixia Wang