Institute of Radiation Medicine, Academy of Military Medical Sciences, Pla.

Institute of Radiation Medicine Academy of Military Medical Science

Beijing Sanly Sci-Tech Develop Inc. Ltd.

Aiping Yu

Zuze Wu

Zhongxiong Tang

Chuanling Zhang

Bingxing Shi

Chunna Dong

This application relates to a fusion protein, which is composed of a thrombolytic protein, an anticoagulant protein, and a linker peptide. In particular, the fusion protein is composed of an anticoagulant protein and a protein molecule having plasminogen-activating activity, wherein said two proteins are linked together via a linker peptide, which can be recognized and cleaved by blood coagulation factors. The application also relates to the medical use of said fusion protein, and to the use of the linker peptide which can be recognized by blood coagulation factor in linking a thrombolytic protein and an anticoagulation protein.

Bifunctional fusion protein with thrombolytic and anticoagulant activities and uses thereof

Provided is an anticoagulant fusion protein comprising oligopeptide recognizable and cleavable by either factor XIa and factor Xa or thrombin and factor Xa. Also provided are the preparation method of the anticoagulant fusion protein and medicinal use thereof.

Preparation of low bleeding anticoagulant fusion protein and its use

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Beijing, China

Aiping Yu