Hong Kong Baptist University

Other

Yunnan Minzu University

Shanghai University of Traditional Chinese

Changshu Hkbu Technology Company Limited

Yunnan University of Nationalities

Aiping Lu

Zhaoxiang Bian

Chengyuan Lin

Dajian Yang

Hongxi Xu

Shilin Chen

Albert Sun Chi Chan

Albert Sun-Chi Chan

Huaixue Mu

Siu Wai Tsang

Kaixian Chen

Baomin Fan

Hongjie Zhang

Hong Jie Zhang

Yongyun Zhou

Sun Chi Albert Chan

Zhijun Yang

Yuanzhi Lao

Xiaoyu Wang

Quanbin Han

Jun Wang

Xin Li

Cheng Wang

Yegao Chen

Qingjing Yang

Jingchao Chen

Ge Zhang

Wenwei Fu

Linfang Huang

Weimin Zeng

Siu Po Ip

Che Yuen Justin Wu

Cheng Lu

Chao Huang

Jun Hu

Haitao Xiao

Biao Liu

Hongyan Qin

Jianbin Xu

Jun Lu

Xiaoyu Chen

Jinjin Wang

Blenda Chi Kwan Wong

Hongsheng Tan

Yue Lv

The present invention provides a slow and controlled released liposomal gel composition for subcutaneous administration comprises insulin or exenatide as active ingredient for reduction of blood sugar level and method of preparation thereof. Said controlled released composition has high bioavailability and is demonstrated to be able to sustain release therapeutically effective concentration of drug over a period of time and without rapid release of drug after initial administration. Method of preparing the controlled released composition of the present invention comprises the following steps: mixing insulin or exenatide, lipid and aqueous dispersion medium together; then mixing with poloxamer (e.g. F127 or P123) and/or gelatin and hyaluronic acid (HA) or the like gel solution so as to form a protective layer on surface of every lipid micro vesicles or nano-vesicles for use in intramuscular, abdominal and subcutaneous administration. A single administration of the present composition lasts 2 to 7 days to reduce side-effects, such as pain and irritation.

Slow and controlled released liposomal gel composition comprising hypoglycemic active ingredient and method of preparing thereof

A compound of formula (I) or a pharmaceutically acceptable salt, hydrate or prodrug thereof for inhibiting Syk activity, 

Method for preventing and/or treating a subject suffering from asthma

Tripyolide-nucleic acid aptamer derivatives, a preparation method and use thereof are shown. The structure of the triptolide-nucleic acid aptamer derivatives is as shown by formula I, wherein the definitions of R-R, G, A, B, M, Z and X are described. The present invention uses a nucleic acid aptamer and triptolide or modified compounds thereof as the starting materials, and introduces a linking group A at the C-14 hydroxyl group, epoxy groups and five-membered ring lactones in triptolide, then connects it to a nucleic acid aptamer B, and obtains the triptolide-nucleic acid aptamer derivatives. The triptolide-nucleic acid aptamer derivatives of the present invention have the characteristics of good targeting, a high anti-cancer activity, low toxicity and side effects, good water solubility and high bioavailability, and the preparation method of the present invention is scientific and reasonable and has a controllable quality and good repeatability, and is thereby suitable for production.

Triptolide derivatives and preparation method and use thereof

This invention relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds. More particularly, it relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds comprising phenylacetophenone derivatives using oxabenzonorbornadienes with terminal alkynes.

Palladium/silver co-catalyzed tandem reactions synthesis of phenylacetophenone derivatives by oxabenzonorbornadienes with terminal alkynes and their anti-tumor or anti-cancer activities

The present invention relates to chemical constituents of the hydro-alcoholic extract of root of(L.) Thwait. More particularly, it relates to the bioactive chemical composition of(L.) Thwait and its anticancer effect. The present invention has application in the treatment of human esophageal carcinoma.

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The present invention relates to the bioactive components with the anti-proliferative property. In particular, the invention relates to one flavonol compound isolated from the root ofLinn. Thwait or chemically synthesized and its specific anticancer/antitumor activity. This invention has a specific application in treating human esophageal cancer.

Anti-esophageal cancer compound and method of use thereof

The present invention relates to a method of using trans-3,5,4'-trihydroxybibenzyl, also known as dihydro-resveratrol for treating acute pancreatitis in a subject in needs thereof. More particularly, the present invention relates to a method of using dihydro-resveratrol, its derivatives and/or chemical variants as a remedial agent. The present invention particularly relates to the amelioration of tissue injury for the management of acute pancreatitis associated pulmonary injury of a subject.

Method of using dihydro-resveratrol for treating acute pancreatitis and associated pulmonary injury

The present invention provides a compound, namely (+)-3'-Angeloyloxy-4&#x2032;-keto-3&#x2032;,4&#x2032;-dihydroseselin (Pd-Ib) derived fromas the potential anti-inflammation drug. The present invention also relates to methods of preparing the compounds and using the same for treating inflammation.

(+)-3'-angeloyloxy-4&#x2032;-keto-3&#x2032;,4&#x2032;-dihydroseselin for treating inflammation

Prostate cancer is the most commonly diagnosed cancer in males and one of the leading causes of cancer death. Although treatment options have increased for some patients, overall progress has been modest. Thus, there is a great need to develop new treatments. This invention relates to a method for treating cancer comprising using an anti-cancer compound of formula (I):  More particularly, it relates to said anti-prostate cancer compound that can be isolated fromor chemically synthesized and its specific anticancer/antitumor activity. The invention has a specific application in treating human prostate cancer.

Pharmaceutical composition comprising guttiferone F for the treatment of prostate cancer

Cervical cancer is one of the most common malignancies and is associated with a dismal prognosis. The most common therapeutic option for cervical cancer consists of surgery in early stages, and chemotherapy or radiotherapy in more advanced stages of the disease. Although treatment options have increased for some patients, overall progress has been modest. This invention relates to a method for treating cancer comprising administering an anti-cancer compound. More particularly, the present invention relates to an anti-cervical-cancer compound for treating human cervical cancer and tumor.

Anti-cervical cancer compound and method of use thereof

A method for suppressing activation of pancreatic stellate cells of a subject includes administering a composition comprising a therapeutically effective amount of Eruberin A. A method of preventing, alleviating or treating pancreatic tumors or pancreatic tumors related diseases includes administering a composition comprising a therapeutically effective amount of Eruberin A. The Eruberin A may be extracted from

Use of a flavanol glycoside for suppressing activation of stellate cells

The present invention relates to chemical entities originated from natural sources and further synthesized for therapeutic uses. More particularly, the present invention relates to norcantharidin analogs synthesized by a transition metal-catalyzed alkynylation of oxanorbornadiene derivatives and their antitumor effects.

Oxanorbornadiene derivatives and their anticancer activities

This invention relates to a Chinese medicinal formulation for the treatment of inflammatory bowel diseases, and a method of preparation thereof. The formulation comprises herbal components selected from a group consisting of Radix Codonopsis (Dangshen), Rhizoma Atractylodis Macrocephalae (Bai Zhu), Sclerotium Poriae Cocos (Fu Ling), Rhizoma Zingiberis Officinalis (Gan Jiang), Radix Paeoniae Alba (Bai Shao) and Rhizoma Coptidis (Huanglian).

Chinese medicinal formulation for treating inflammatory bowel disease and the preparation thereof

The present invention relates to a type of norcantharidin analogues and a method to synthesis such norcantharidin analogues by transition metal-catalyzed alkynylation of 7-oxabenzonorbornadienes. The present invention also relates to the use of such norcantharidin analogues in manufacture of a medicament for the treatment of cancer tumors.

Asymmetric synthesis of norcantharidin analougus by alkynylation of oxabenzonorbornadienes and their anticancer activities

The present invention relates to a method of using an anthraquinone derivative namely 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, or known as Rhein, for treating chronic pancreatitis induced fibrosis of the pancreas. More particularly, the present invention relates to a method of using Rhein, its derivatives and/or chemical variants as an anti-fibrotic agent. The present invention particularly relates to the suppression of pancreatic stellate cell activation for the management of chronic inflammatory, fibrotic and tumorigenic pathologies in the pancreas.

Method of using rhein for treating fibrotic conditions and tumors

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Hong Kong, China

Aiping Lu