Karo Bio Ab

Wyeth

Karo Pharma Ab

Aiping Cheng

Theresa Apelqvist

Patrik Rhönnstad

Lars Hagberg

Mattias Wennerstål

Elisabet Kallin

Jay Edward Wrobel

Robert J Steffan

Rayomand Jal Unwalla

John W Ullrich

Joakim Löfstedt

Christopher P Miller

Konrad Koehler

Edouard Zamaratski

Neeraj Garg

Lars Krüger

Sandra Gordon

Edward Martin Matelan

Stephen Marc Bowen

Lars Kruger

Annabel L Olsen Hedemyr

Tomas Hansson

Daniel Nöteberg

Eva Koch

Lars KRÜGER

Joakim LÖFSTEDT

Daniel NÖTEBERG

Mattias WENNERSTÅL

Patrik RHÖNNSTAD

Compounds of formula (I) or a pharmaceutically acceptable ester, amide, carbamate or salt thereof, including a salt of such an ester, amide or carbamate in which Rto Rhave meanings as defined in the Specification, are useful as estrogen receptor ligands. 

Estrogen receptor ligands

The invention provides a compound of formula(I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt. The invention also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity. Formula(I) wherein R, R, R, R, R, R, R, R, Rand Rare as defined in the specification. 

The invention provides a compound of formula (I) or a pharmaceutically acceptable ester, amide, carbamate, solvate or salt thereof, including a salt of such an ester, amide or carbamate, and a solvate of such an ester, amide, carbamate or salt. The invention also provides also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity, wherein R, R, R, Rand Rare as defined in the specification. 

The invention provides a compound of formula (I) or a pharmaceutically acceptable ester, amide, carbamate, solvate or salt thereof, including a salt of such an ester, amide or carbamate, and a solvate of such an ester, amide, carbamate or salt. The invention also provides also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity, wherein R, R, R, R, Rand Rare as defined in the specification. 

This invention provides compounds of Formula (I) or (Ia): that are useful in the treatment or inhibition of LXR mediated diseases.

Indazoles

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Huddinge, Sweden

Aiping Cheng