Universidad De Zaragoza

Ainhoa Arbues Arribas

Esther Perez Herran

Carlos Martin Montanes

Brigitte Gicquel

Jesus Gonzalo Asensio

The present invention relates to an isolated microorganism belonging to the genus, characterized in that it comprises inactivating the gene Rv0757 that confers a PhoP&#x2212; phenotype and inactivating a second gene that prevents the production of DIM (DIM-phenotype). Additionally, the present invention comprises the use of said microorganism for producing a vaccine for immunizing against or preventing tuberculosis.

Tuberculosis vaccine

An isolated microorganism belonging to the genus, having one or both of an inactivated gene Rv0757 that confers a PhoP&#x2212; phenotype and an inactivated second gene which prevents the production of DIM (DIM&#x2212; phenotype). Methods of making the microorganism, related pharmaceutical formulations and vaccines are also provided, as are related methods of treatment and vaccination. The pharmaceutical formulation may also serve as a vector or adjuvant.

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Zaragoza, Spain

Ainhoa Arbues Arribas