Ab Ferrosan

Other

Pharmacia Ab

Aktiebolaget Leo

Aina L Abramo

Erik G Christensson

Knut G Olsson

Anders K Bjork

Sven E Hernestam

Bengt Erik Kjellberg

Tomas Fex

Curt Nordvi

Bengt K Gustafsson

Lars O Willard

Hans-Bertil Johansson

Torbjorn E Lundstedt

Erik T Lundstedt

The present invention concerns novel compounds of the general formula; ##STR1## wherein R.sub.1 is halogen or hydrogen and R.sub.2 is halogen; X is either oxygen, sulfor or methylene

Pyridyl-and pyrmidyl-piperazines useful for the treatment of mental

Bisphenylalkylpiperazine derivatives, a method of their preparation and

A series of 1-piperazinecarboxamide derivatives of the following formula: ##STR1## The compounds of the present invention are neuropharmacological agents intended for the treatment of mental disorders, such as psychoses and depression.

Novel 1-piperazinecarboxamide derivatives

Piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side

Diphenylbutyl-1-acylpiperazines

Compounds having the general formula ##STR1## as herein defined and pharmaceutically acceptable acid addition salts thereof. Pharmaceutical compositions containing said compounds. Methods of treatment of humans and animals by such compounds and compositions.

Diphenylbutyl-piperazinecarboxamides to treat pain

Diphenylbutyl-piperazinecarboxamides in pharmaceutical compositions and

Aryl ethers of N-alkyl-piperdines having the formula ##STR1## wherein R.sub.1 represents hydrogen, halogen including F, Cl and Br, a lower alkanoyl group (e.g. alkanoyl of up to five carbon atoms), an alkenyl group (having three to five carbon atoms) or phenoxy, R.sub.2 represents hydrogen, halogen including F, Cl and Br, --CN group, a lower alkoxy group (e.g. alkoxy of up to five carbon atoms), a lower alkanoyl group (e.g. alkanoyl of up to five carbon atoms), an alkenyloxy or alkynyloxy group (having three to five carbon atoms) or a lower alkoxycarbonyl group (e.g. alkoxycarbonyl of up to five carbon atoms), R.sub.3 and R.sub.4 independently represent hydrogen, halogen including F, Cl and Br, a --CF.sub.3 group, a lower alkyl group (e.g. alkyl of up to five carbon atoms) or a lower alkoxy group (e.g. alkoxy of up to five carbon atoms), R.sub.5 represents hydrogen or an acyl group with 2-19 carbon atoms and n=3 or 4, and pharmaceutically acceptable acid addition salts. Pharmaceutical compositions containing said substances. Said substances are active in the central nervous system.

Aryl ethers of N-alkyl-piperidines and acid addition salts thereof

Diphenylbutyl-piperzinecarboxamides

Novel alkyl 1-(hydroxyalkyl)piperidines and acid addition salts thereof, useful as inhibitors of dental plaque and therefore also useful against dental caries and periodontitis, are disclosed. Methods of making same, orally-acceptable compositions thereof, a method of treating therewith, and important and novel intermediates for the production thereof are also disclosed.

Anticaries piperidino compounds

2,3,4,7,8,9-Substituted octahydropyrazinopyrimidinones and acid addition salts thereof. A process for the preparation of said compounds. A pharmaceutical composition comprising such a compound and a conventional carrier. A process for the preparation of said composition. Method of medical treatment of human beings and animals using such compounds.

Diarylbutyl octahydropyrazinopyrimidinones and methods of medical

Growing community of inventors

Bjarred, Sweden

Aina L Abramo