Ludwig Institute for Cancer Research Limited

Ailsa G Harpur

Andrew Frederick Wilks

Andrew Ziemiecki

Sandra Elaine Nicholson

Judith E Layton

Andrew C Oates

The present invention is directed to a novel protein tyrosine kinase comprising a polypeptide having multiple protein kinase catalytic domains and, more particularly, two kinase catalytic domains and to genetic sequences encoding same. Two such kinases are described and designated JAK1 and JAK2.

Protein tyrosine kinase

Antibodies which bind the G-CSF receptor extracelluar domain and methods

The invention relates to a method of determining the presence of a tyrosine kinase in a sample using antibodies that specifically bind to kinase active proteins. The proteins have more than one tyrosine kinase domain and no SH2 domains. Exemplary proteins are the Janus Kinases, or 'JAK1' and 'JAK2.' Both polyclonal and monoclonal antibodies are used in the detection method.

Method for determining tyrosine kinase in a sample

The invention relates to antibodies which specifically bind to tyrosine kinase active proteins. The proteins have more than one protein kinase domain, and no SH2 domains. Exemplary proteins are the Janus Kinases, or 'JAK1' and 'JAK2'. Both polyclonal and monoclonal antibodies are a part of the invention, as are hybridomas which produce the monoclonal antibodies.

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Mooroolbark, Australia

Ailsa G Harpur