Megmilk Snow Brand Co., Ltd.

Aiko Ono

Yoshikazu Morita

Atsushi Serizawa

Hiroshi Ueno

Hiroaki Matsuyama

Satoshi Higurashi

Daisuke Uetsuji

Hiroshi Kawakami

Ken Kato

Noriko Ueda

Ken Katoh

A problem of the present invention is to provide a skin collagen production-promoting agent without safety problems. Another problem of the present invention is to provide a skin collagen production-promoting food or drink product and a skin collagen production-promoting cosmetic product containing such a substance. TGF-&#x3b2; and/or a TGF-&#x3b2; degradation product, which is acquired by degrading TGF-&#x3b2; with a protease such as pepsin, pancreatin, etc., are used as a skin collagen production-promoting agent or the active ingredient of a skin collagen production-promoting food or drink product and a skin collagen production-promoting cosmetic product. The aforementioned TGF-&#x3b2; and/or TGF-&#x3b2; degradation product have an effect of increasing the collagen content of the skin.

Skin collagen production-promoting agent

A milk protein fraction having following properties (1) to (4) is excellent in bone resorption inhibitory effect, and is useful for preventing or treating bone diseases:

Bone resorption inhibitory food material for inhibiting bone resorption

Disclosed is a bone-reinforcing agent which comprises a milk protein fraction having the following properties (1) to (4): (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein component having a molecular weight of 6,000 to 150,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 12 to 14 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.5 to 0.7; and (4) the milk protein fraction has an activity of accelerating the calcification in an osteoblast.

Bone-reinforcing food material

A determination method quantifies a specific protein or peptide contained in a trace amount with high accuracy and in a simple manner without the need of using any expensive reagent. A protein or peptide of interest can be quantified by LC/MS/MS by using, as an internal standard, a protein or peptide including an amino acid sequence having the reshuffling the binding order of amino acid residues in the amino acid sequence for the protein or peptide of interest.

Method for quantification of peptide and protein

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Saitama, Japan

Aiko Ono