Centro De Ingenieria Genetica Y Biotecnologia

Centro De Ingenieria Genetica Y Biotechnologia

Centro De Ingeniera Genetica Y Biotecnologia

Aida Zulueta Morales

Gerardo Enrique Guillen Nieto

Lisset Hermida Cruz

Laura Lazo Vazquez

Rayner Rodriguez Diaz

Carlos Lopez Abarrategui

Iris Valdes Prado

Maria Guadalupe Guzman Tirado

Beatriz De La Caridad Sierra Vazquez

Raul Rafael Espinosa Perez

Glay Chinea Santiago

Ricardo De La C Silva Rodriguez

Richardo De La C Silva Rodriguez

Maria Guadalupe Guzmán Tirado

Iris Valdez Prado

Susana Vázquez Ramundo

Beatriz De La Caridad Sierra Vázquez

Carlos López Abarrategui

Laura Lazo Vázquez

Susana Vazquez Ramundo

Beatriz De Sierra Vazquez

The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein fromwith dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.

Chimeric proteins that induce effects directed against viruses

This invention describes a pharmaceutical compound which has the capsid protein of Dengue virus and which is capable of inducing, in the receptor, a protective immune response before the viral challenge, without inducing the Ab-dependent enhancement phenomenon.

Pharmaceutical compound capable of induce immune protective response against Dengue virus having the capsid protein of the Dengue virus

The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonspecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein fromwith dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.

Growing community of inventors

Ciudad de la Habana, Cuba

Aida Zulueta Morales