Otsuka Pharmaceutical Company, Limited

Theravance Biopharma R&d Ip, LLC

Ai Ling Ching

Kurt Scheinpflug

Chris Dong

Nikhil Pargaonkar

Dawn Adkin

Hooman Hafezi

Venkat R Thalladi

Patricia Johnson

Raymond H Schmidt

Kevin K Cheng

Raymond Schmidt

David L Bourdet

Kosuke Iwai

Anuj Patel

Nathan Schulpen

Yvonne Rosiaux

Jens Maes

Bernardus Joseph Nitert

Marian E Van Der Veen

Guido Verniest

Marie T Borin

Arthur Lo

The present disclosure relates to pharmaceutical compositions comprising (3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile), methods of use thereof, and methods of preparation.

Formulation of a pan-JAK inhibitor

Provided herein are compositions for the ingestible administration of lisinopril. In some embodiments the compositions comprise lisinopril and silicon. In some embodiments, the compositions comprise lisinopril, silicon, magnesium metal, and copper (I) chloride. Also provided herein are apparatuses comprising the compositions provided herein. Also provided herein are methods for using the compositions and apparatuses provided herein.

Lisinopril compositions with an ingestible event marker

Methods of safely administrating a gut-selective JAK3 inhibitor by oral administration are described. Also described are methods for providing clinically proven safe treatment of gastrointestinal inflammatory diseases, such as celiac disease, by oral administration of a gut-selective JAK3 inhibitor.

Administration of gut-selective JAK3 inhibitor

An ingestible compositions includes a first polymer layer, an adhesive layer associated with the first polymer layer, where the adhesive layer includes an adhesive material and is configured to releasably adhere to the first polymer layer, an alginate layer adhered to the adhesive layer, and a second polymer layer associated with the alginate layer and configured to releasably adhere to the alginate layer. Aspects further include methods of making and using the compositions.

Alginate on adhesive bilayer laminate film

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San Francisco, CA, United States of America

Ai Ling Ching