Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Hadasit Medical Research Services and Development Ltd.

Qbi Enterprises Ltd.

Ahuva Itin

Eli Keshet

Shay Sela

Ilan Stein

Simcha Yagel

An isolated polypeptide comprising an amino acid sequence at least 70% homologous to SEQ ID NO: 4 and an isolated polynucleotide encoding same are disclosed. A polynucleotide comprising a nucleic acid sequence capable of specifically hybridizing to the isolated polynucleotide and an isolated antibody comprising an antigen recognition domain which specifically binds the isolated polypeptide are also disclosed. Pharmaceutical compositions, methods of diagnosing and treating comprising same are also disclosed.

Composition for use in detection of sFlt-14

An isolated and cloned translation control element, and analogues thereof, having the nucleotide sequence as set forth in SEQ ID NO:7 and designated SP163, are disclosed. The translation control element controls cap-independent mRNA translation via an internal ribosome entry site (IRES). The present invention provides expression vectors comprising the translation control element SP163 or its analogues operatively linked to a gene sequence to be expressed. In alternative embodiments, the expression vector comprises at least two nucleic acid sequences to be translated and SP163 is operatively linked to at least one of the sequences to be translated. The sequences to be translated may be linked to only one promoter in an embodiment. The present invention further provides a method for facilitating and enhancing cap-independent translation of mRNA by including in an expression cassette a translation control element having the nucleotide sequence as set forth in SEQ ID NO:7 and designated SP163.

IRES sequences with high translational efficiency and expression vectors containing the sequence

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Jerusalem, Israel

Ahuva Itin