Max-planck-gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

Medizinische Hochschule Hannover

Ahmet Ucar

Thomas Thum

Shashi Kumar Gupta

Kamal Chowdhury

The present invention refers to inhibitors of microRNAs, particularly of microRNAs miR-212 and/or miR-132 for use in medicine, particularly in the diagnosis, treatment or prevention of cardiac disorders, e.g. cardiac hypertrophy-associated or autophagic disorders, and further refers to isolated nucleic acid molecules, particularly microRNAs miR-212 and/or miR-132 and related sequences, for use in medicine, particularly human medicine, more particularly in the diagnosis, treatment or prevention of disorders involving cardiac atrophy and/or dysfunctional autophagy, e.g. cardiac cachexia.

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Heidelberg, Germany

Ahmet Ucar