Biopep Solutions, Inc.

Chemokine Therapeutics Corporation

The University of British Columbia

British Canadian Biosciences Corp

Ahmed Merzouk

Abdualrahman M Abdualkader

Abbas Mohammad Ghawi

Mohamed Alaama

Hassan Salari

Geeta Saxena

Christopher R Tudan

Connie J Eaves

Donald Wong

Carolina Abramovich

Lakhdar Arab

Johanne Cashman

Ian Clark-Lewis

Mohammad Alaama

Abdelkrim Habi

Mary A Richter, Legal Representative

Michael Clark-Lewis, Legal Representative

Methods are also provided for isolating and using a whole-saliva leech extract in the treatment of a bacterial skin infection. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0&#xb0; C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5&#xb0; C. to about 40&#xb0; C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about &#x2212;20&#xb0; C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.

Treating a bacterial skin infection with a whole, leech saliva extract

Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0&#xb0; C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5&#xb0; C. to about 40&#xb0; C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about &#x2212;20&#xb0; C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.

Treating damaged dermal or mucosal tissue with a whole, leech saliva extract

Methods are also provided for isolating and using a whole-saliva leech extract in the treatment of a melanoma. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0&#xb0; C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5&#xb0; C. to about 40&#xb0; C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about &#x2212;20&#xb0; C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.

Treating a lymphoma with a whole, leech saliva extract

Treating renal cancer with a whole, leech saliva extract

Treating a melanoma with a whole, leech saliva extract

Treating colorectal cancer with a whole, leech saliva extract

Treating a parasitic disease with a whole, leech saliva extract

Methods are also provided for isolating and using a whole-saliva leech extract in the treatment of pancreatic carcinoma. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0&#xb0; C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5&#xb0; C. to about 40&#xb0; C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about &#x2212;20&#xb0; C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.

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Richmond, CA, United States of America

Ahmed Merzouk