Virbac Sa

Carbomimetics

Ahmed El Hadri

Maurice Petitou

Arthur Donny Strosberg

Gérard Leclerc

France Pietri-Rouxel

Philippe Archimbault

The invention concerns a pentasaccharide compound of formula (I)  The invention also concerns a pharmaceutical composition comprising the synthetic pentasaccharide compound of formula (I) and its salts. The invention further concerns these compounds for use as a medicament, and in particular intended to treat blood clotting disorders, to prevent ischaemia reperfusion injury associated with solid organ transplantation, or to reduce the risk of blood clotting in an extracorporeal blood circuit during cardiac surgery, extracorporeal membrane oxygenation, or during circulatory assistance such as artificial heart.

Synthetic pentasaccharides having short half-life and high activity

The invention concerns aryloxypropanolamine derivatives having at least an anti-diabetic and anti-fat activity and their methods of preparation and applications, particularly as human and veterinary medicine and animal food additive. These derivatives comply with the general formula (I) in which Rrepresents one of the following groups: &#x2014;CH&#x2014;, &#x2014;CH&#x2014;CH, &#x2014;CH(CH)&#x2014;CH&#x2014;, &#x2014;C(CH)&#x2550;CH&#x2014;, &#x2014;C(CH)&#x2014;CH&#x2014; or a bond; Q represents: (i) a phenyl radical 3,4-disubstituted alkylene dioxy determining with the phenyl radical, a non-substituted benzodioxane unit, a non-substituted benzodioxol unit, or a 2-substituted benzodioxol unit, (ii) a phenyl radical 3 and/or 4-substituted, by a O&#x2014;(CH)&#x2014;COORgroup, (iii) a condensed polycyclic hydrocarbon comprising at least two condensed cycles, (iv) a cyclic hydrocarbon system, optionally cross-linked, and constituting a cycloalkane comprising 1, 2 or 3 cycles

Aryloxypropanolamine derivatives, method of preparation and applications thereof

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Morsang sur Orge, France

Ahmed El Hadri