Chong Kun Dang Pharmaceutical Corporation

Shin Poong Pharmaceutical Co., Ltd.

Ah-Reum Chae

Jae-Young Lee

Young Nam Lee

Jong Lae Lim

Min Hyo Ki

Ji Hee Lee

Ho Young Hwang

Sang Myoung Noh

Hee-Jeong Cho

Woo-Ile Park

Kyoung-Hwan Kang

Soo-Won Kim

Jei-Man Ryu

Hyun-Woo Jung

Woo-Kyung Kim

Disclosed is a pharmaceutical composition for gene delivery, comprising: (i) a gene; (ii) a water-soluble chitosan; (iii) a thiamine pyrophosphate or a pharmaceutically acceptable salt thereof; (iv) a protamine or a pharmaceutically acceptable salt thereof; and (v) a neutral or anionic phospholipid. The composition can introduce a gene into cells safely and effectively. Composed of non-toxic and injectable components, the composition is safe for the body and can be advantageously commercialized. Notably, it can deliver a gene at high efficiency in vivo as well as in vitro, and is stable in the blood.

Composition for gene delivery

Growing community of inventors

Seoul, South Korea

Ah-Reum Chae