Other

Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr

Institut Organicheskoi Khimii Akademii Nauk Ukrainskoi Ssr

Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi

Institut Organischskogo Sinteza Akademii Nauk Ssr

Agris A Kimenis

Gunar Y Dubur

Rasma O Vitolin

Maris M Veveris

Egils A Biseniex

Yan R Uldrikis

Valeria V Kastron

Lev Moiseevich Yagupolsky

Yan-Voldemar Y Ozol

Gunta O Silenietse

Brigita A Vigante

Natalya V Kondratenko

Edmund Y Lukevits

Vladimir I Popov

Alexandr A Kolomeitsev

Evgeny V Ivanov

Svetlana V Shelyazhenko

Jury A Fialkov

Elena L Khanina

Natalya V Makarova

Nikolai P Erchak

Indulis P Skrastinsh

Natalia V Barmenkova

Yanis J Polis

Novel compounds, that is, alkoxy- and phenoxy-alkyl esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxy li c acid have the following general formula useful for producing hypotensive and vasodilation effects. ##STR1##

Alkoxy-and phenoxy alkyl esters of

2,6-dimethyl-3,5-dimethoxycarbonyl-4-(5'-tri

The present invention relates to organic chemistry. The novel compound 2-oxo-4-(2'-difluoromethylthiophenyl)-5-methoxycarbonyl-6-methyl-1,2,3,4-t etrahydropyrimidine has the formula: ##STR1## Said compound displays coronary-dilating activity and can be utilized in medicine.

2-oxo-4-(2'-difl

A compound 2,6-dimethyl-3,5-bis-(1-adamantylhydroxycarbonyl)-4-(2-difluoromethoxyphen yl)-1,4-dihydropyridine of the formula ##STR1## is proposed. Said compound possesses antianginal activity.

2,6-Dimethyl-3,5-bis-(1-adamantylhydr

2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamide) glutaric acid of formula I and its disodium salt of formula II ##STR1## Said acid is obtained from glutaminic acid and dimethyl 3,5-diethoxycarbonyl-1,4-dihydroisonicotic acid. For obtaining disodium salt, said acid is reacted with a caustic soda solution. These compounds possess antiarrhythmic activity.

2-(2,6-Dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamide

The present invention relates to compounds which are derivatives of 1,4-dihydropyridine-3-carbothiol acids of the formula: ##STR1## wherein R is hydrogen, an alkyl, aryl, heteryl;

Derivatives of 1,4-dihydropyridine-3-carbothiol acids

The present invention relates to derivatives of 1,4-dihydropyridine and, more specifically, to 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(o-difluoromethoxyphenyl)-1,4-dihydro pyridine of the formula: ##STR1## This compound features a clearly pronounced hypotensive activity while being low-toxic, wherefore it can be used in medicine for treating hypertensive disease.

2,6-Dimethyl-3,5-dimethoxycarbonyl-4-(ortho-difluoromethoxyphenyl)-1,4-di

Growing community of inventors

Riga, undefined

Agris A Kimenis