Biogal Gyogyszergyar

Agota Hulber Nee Dobos

Imre Moravcsik

Gabor Ambrus

Attila Andor

Janos Erdei

Karoly Albrecht

Valeria Szell

Gyorgy Santha

Antonia Jekkel Nee Bokany

Kalman Konczol

Eva Toth-Sarudy

Kalman Polya

Bela Makadi

Karoly Nagy

Eva Tomori Nee Joszt

Lajos Kiss

Bela Palotas

Karoly Buzasi

Etelka Deli Nee Konszky

Aniko Molnar Nee Antal

Vilma Szaszhegyesi

Istvan Mihaly

The invention relates to a microbial process for the production of immunosuppressive cyclosporine antibiotic complex or of its components, cyclosporine A, cyclosporine B and cyclosporine C, by the aerobic fermentation of a filamentous fungus strain biosynthesizing the above antibiotic(s) in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the products formed, which comprises culturing a strain of the novel Tolypocladium varium fungus species producing the cyclosporine antibiotic complex, preferably tolypocladium varium sp. nov. CY/93, deposited at the National Collection of Agricultural and Industrial Microorganisms, Budapest, Hungary under the number NCAIM(P)F 001005, on a nutrient medium containing carbon sources, organic and inorganic nitrogen sources as well as mineral salts, under aerobic conditions, at 25.degree. to 30.degree. C., and, if desired, isolating and purifying the cyclosporine antibiotic complex or its components produced.

Microbial process for the production of immunosuppressive antibiotics

Growing community of inventors

Budapest, Hungary

Agota Hulber Nee Dobos