Ionwerks, Inc.

Agnès Tempez

Thomas F Egan

J Albert Schultz

Michael V Ugarov

Valeri V Raznikov

Vladislav V Zelenov

Marina O Raznikova

Valerie E Vaughn

Yvon Le Beyec

Alexander R Pikhtelev

Gennadiy Savenkov

Valeriy V Raznikov

Serge D Negra

Serge Della-Negra

Valentin A Tarasenko

The content of the invention comprises a concept of reactor for isolated ion transformations induced by collisions with neutral species. This reactor is also an interface between mobility cell and orthogonal injection TOFMS based on supersonic adiabatic gas flow with variable controlled composition directed along the axis of a multipole ion guide with sectioned rods for possibility of creating of controlled distributions of RF, DC and AC rotating fields.

Neutral/ion reactor in adiabatic supersonic gas flow for ion mobility time-of-flight mass spectrometry

The content of the invention comprises a concept of multi-beam ion pre-selection from a single sample, coordinated mobility (against the gas flow) separation, cooling ions in supersonic gas flow and mass separation of thus low divergent ions by single or plural compact high-resolution orthogonal time-of-flight mass spectrometers both linear or reflectron type with controlled collision-induced dissociation (CID) and multi-channel data recording for the optimization of sample use in the analysis, and obtaining as much useful information about the sample as possible in a reasonably short time.

Multi-beam ion mobility time-of-flight mass spectrometry with multi-channel data recording

The present invention enhances the laser desorption of biological molecular ions from surfaces by creating a surface localized MALDI particle matrix by ion implantation of low energy ionized clusters (gold, aluminum, etc.) or chemically derivatized clusters into the near surface region of the sample. MALDI analysis of the intact biomolecules on the surface or within a narrow subsurface region defined by the implantation range of the ions can then be performed by laser desorption into a mass spectrometer or, in a preferred embodiment, into a combined ion mobility orthogonal time of flight mass spectrometer.

Gold implantation/deposition of biological samples for laser desorption two and three dimensional depth profiling of biological tissues

Neutral/Ion reactor in adiabatic supersonic gas flow for ion mobility time-of-flight mass spectrometry

The present invention relates generally to instrumentation and methodology for the characterization of chemical samples in solutions or on a surface which is based on modified ionization methods with or without adjustable pH and controllable H-D exchange in solution, in improved ion mobility spectrometer (IMS), a multi-beam ion per-selection of the initial flow, and coordinated mobility and mass ion separation and detection using a single or several independent time-of-flight mass spectrometers for different beams with methods for fragmenting ion mobility-separated ions and multi-channel data recording.

Multi-beam ion mobility time-of-flight mass spectrometer with bipolar ion extraction and zwitterion detection

Improved ion focusing for an ion mobility drift cell allows for improved throughput for subsequent detection such as mass detection. Improved focusing is realized by the use of alternating regions of high and low electric fields in the ion mobility drift cell.

Ion mobility TOF/MALDI/MS using drift cell alternating high and low electrical field regions

Gold implantation/deposition of biological samples for laser desorption three dimensional depth profiling of tissues

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Houston, TX, United States of America

Agnès Tempez