Latvian Institute of Organic Synthesis

Grindeks, a Joint Stock Company

Agnija Ievina

Ivars Kalvins

Ivars Kalvinsh

Aleksandrs Chernobrovijs

Maksims Vorona

Grigory Veinberg

Antons Lebedevs

Pugovics Osvalds

The present invention provides a method for regeneration of chiral 2,2'-cyclopropylidene-bis(oxazolines), such as (3&R,3&#x2032;aR,8aS,8&#x2032;aS)-2,2&#x2032;-cyclopropylidenebis-[3a,8a]-dihydro-8H-indeno-[1,2-d]-oxazole and (45,4&#x2032;5,5R,5&#x2032;R)-2,2&#x2032;-cyclopropylidenebis-4,5-diphenyldihydro-4,5-oxazole, used as a part of complex catalysts for e.g. stereoselective addition reactions, from the reaction mixtures, by selective sorption of 2,2&#x2032;-cyclopropylidene-bis(oxazolines) on a sorbent, such as silica gel, isolation of the sorbent from reaction mixture, desorption of 2,2&#x2032;-cyclopropylidene-bis(oxazolines) from the sorbent with suitable organic solvent and final recovery of 2,2&#x2032;-cyclopropylidene-bis(oxazolines) from the organic solvent used for desorption process. Catalytic quality of recovered compounds does not differ from those in freshly prepared catalysts.

Regeneration of 2,2'-cyclopropylidene-bis (oxazolines)

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Riga, Latvia

Agnija Ievina