Instytut Chemii Bioorganicznej Pan

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Agnieszka Fedoruk-Wyszomirska

Marcin Krzysztof Chmielewski

Jan Barciszewski

Eliza Wyszko

Katarzyna Rolle

Maria Markiewicz

Wojciech T Markiewicz

Ewelina Adamska

Tadeusz Kulinski

Beata Plitta

Malgorzata Giel-Pietraszuk

Miroslawa Naskret-barciszewska

Agnieszka Belter

Monika Piwecka

Patrycja Sosinska

A cytosine analog, a method of preparation of a cytosine analog, a DNA methyltransferase 1 inhibitor, and a method for DNA methylation inhibition, is provided for the treatment of diseases associated with deviations from normal DNA methylation. The analog of cytosine may be comprised of 1, N, 5 and 6-substituted derivatives of cytosine or 5,6-dihydrocytosine, wherein the analog can be described by the chemical formula  where Ris H, R, R, 2'-deoxyribosyl, Ris alkyl or aryl, X is N or C, wherein if X in the analog of formula I is N, then Ris no substituent and if X in the analog of formula I and/or II is C or if X in the analog of formula II is N, then Rand Rare independently alkyl, aryl, hydroxyalkyl, aminoalkyl, hydroxyl, carboxyl, amino group, alkoxyl, aryloxyl, aminoalkyl, aminoaryl, thio group, sulfonyl, sulfinyl or halogen.

Cytosine analogue, a method of preparation of a cytosine analogue, a DNA methyltransferase 1 inhibitor, a method for DNA methylation inhibition, the use of the analogue in the treatment of diseases associated with deviations from normal DNA methylation

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Poznan, Poland

Agnieszka Fedoruk-Wyszomirska