Egis Gyogyszergyar

Egyt Gyogyszervegyeszeti Gyar

Egis Gyogyszergyar Rt.

Agnes Kovacs Nee Palotai

Gabriella Rmos Nee Lassu

Lujza E Petocz

Gabor Blasko

Edit Berenyi Nee Poldermann

Ivan Beck

Geza Schneider

Andras Dietz

Ilma Dinnyes Nee Nagy

Ibolya Kosoczky

Eniko Szirt Nee Kiszelly

Laszlo Pallos

Peter Tompe

Peter Gorog

Laszlo Varga

Judit Kun

Elemer Jakfalvi

Laszlo Ladanyi

Eva Hartai Nee Zsorzs

Elemer Jakflavi

The invention relates to a novel process for preparing 1-[/2S/-methyl-3-mercaptopropionyl]-pyrrolidine-/2S/-carboxylic acid of the formula I ##STR1## in which 1-[/2S/-methyl-3-thiocyanatopropionyl]-pyrrolidine-/2S/-carboxylic acid of the formula II ##STR2## is dissolved in an aqueous mineral acid, the solution obtained is diluted with water and the 1-[/2S/-methyl-3-carbamoylthiopropionyl]-pyrrolidine-/2S/-carboxylic acid of the formula III ##STR3## that forms is hydrolized with an aqueous solution of a base.

Process for preparing 1-[/2S/-methyl

The invention relates to a novel process for preparing 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline (captopril) of formula (I). ##STR1## which comprises hydrogenolysing 1-[(2S)-2-methyl-1-oxo-3-rhodanidopropyl]-L-proline of formula (II) ##STR2## in an inert solvent, in the presence of a catalyst, at a temperature of 50.degree. to 120.degree. C. under a pressure of 10.sup.5 to 10.sup.7 Pa. The above compound of formula (II) is new and can be prepared by acylating L-proline with a reactive acylating derivative of (2S)-2-methyl-3-rhodanido-propionic acid of formula (III). ##STR3##

Process for preparing 1-(2S)-3-mercapto-methyl-1-oxopropyl)-L-proline

The invention relates to new quinoline derivatives of the general Formula I ##STR1## (wherein X stands for hydrogen, halogen or lower alkoxy;

Quinoline derivatives and pharmaceutical compositions

The invention relates to novel pyrazolo[1,5-c]quinazoline derivatives of the general formula I ##STR1## wherein R represents a hydrogen atom, a C.sub.1-4 alkyl group or an acyl group,

Pyrazolo[1,5-c]quinazoline derivatives and analgesic compositions

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Budapest, Hungary

Agnes Kovacs Nee Palotai