Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Agnes Horvath

Istvan Hermecz

Zoltan Meszaros

Lelle V Vasvari Nee Debreczy

Judit Sipos

Sandor Virag

Jozsef Knoll

Tibor Breining

Lelle Vasvari

Aniko Pajor

Peter Ritli

Maria Balogh

Geza Kereszturi

Gabor Kovacs

Jozsef Kokosi

Tamas Szuts

Agoston David

Gyula Sebestyen

Peter Szentmiklosi

Laszlo Tardos

Katalin Marmarosi

Klara Gyires

Gyorgy Szasz

Gabor Horvath

Attila Mandi

Gabor Nagy

Istvan Bitter

Maria Blaogh

Jozsef Szejtli

Jozsef Gaal

Iren Munkacsi

Tamas Szucs

Lelle Vasvari, Nee Debreczy

Zoltan Meszaros, Deceased

Zoltan Kapui

Katalin Marmarosi Nee Kellner

Lajos Szente

Jeno Marton

Jozsef Lengyel

Maria Vikmon

Peter Dvortsak

Maaria Vikmon

Geza Keresturi

Lelle V Debreczy

Ilona Papp

Ilona Erdelyi

Peter Szentmiklosy

Piroska Simon

Lelle Vasvari Nee Debreczi

Istvan Bitteer

Lelle Vasuarl Nee Debreczy

Istvan Hermes

Geza Kerszturi

Maria Halogh

Marie Balogh

Jozse Knoll

Istvan Hurmecz

Lelle Vasvavi

Laszo Tardos

Lelle Vasvari (nee Debreczy)

Katalin Marmarosi (nee Kellner)

Hermecz: Istvan

3-(substituted tetrazolyl)-4-oxo-4H-pyrido-[1,2-a]pyrimidines, salts

Inclusion complexes of N-ethoxycarbonyl 1-3-morpholino-sydnonimine or

The present invention relates to novel 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxamide derivatives of the general formula (I) and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I) ##STR1## R stands for a C.sub.1-12 alkyl group optionally substituted by a C.sub.1-4 alkoxycarbonyl group; a C.sub.3-9 cycloalkyl, adamantyl or optionally substituted phenyl group;

Pyridopyrimidine derivatives, pharmaceutical compositions containing

The invention relates to a new process for the preparation of antibacterial compounds of the Formula I ##STR1## wherein R.sup.1 stands for phenyl substituted by 1 or 2 halogen atoms;

Process for the preparation of quinoline carboxylic acid derivatives

The invention relates to a new process for the preparation of compounds of the general Formula I ##STR1## wherein R stands for piperazinyl, 4-methyl-piperazinyl or 4-ethyl-piperazinyl group and pharmaceutically acceptable salts thereof which comprises reacting a compound of the general Formula II ##STR2## wherein R.sup.1 and R.sup.2 stand for halogen, for an aliphatic acyloxy group containing 2 to 6 carbon atoms and optionally substituted by halogen, or for an aromatic acyloxy group containing 7 to 11 carbon atoms with a piperazine derivative of the general Formula III ##STR3## wherein R.sup.3 stands for hydrogen, methyl or ethyl or a salt thereof and subjecting the compound of the general Formula IV ##STR4## thus obtained wherein R, R.sup.1 and R.sup.2 are as stated above to hydrolysis after or without isolation and if desired converting the compound of the general Formula I thus obtained into a salt thereof or setting free the same from its salt. The compounds of the general Formula I are known antibacterial agents.

Process for the preparation of quinoline carboxylic acids

Inclusion complexes of 3-morpholino-sydnonimine or its salts or its

The invention relates to a new process for the preparation of compounds of the Formula I ##STR1## (wherein R stands for hydrogen or methyl) and pharmaceutically acceptable salts thereof which comprises reacting a compound of the Formula V ##STR2## (wherein R.sup.1 and R.sup.2 stand for an aliphatic acyloxy group comprising 2-6 carbon atoms and optionally substituted by halogen: or for an aromatic acyloxy group comprising 7-11 carbon atoms) with an amine of the Formula VI ##STR3## (wherein R has the same meaning as stated above) or a salt thereof and subjecting the compound of the Formula VII ##STR4## thus obtained (wherein R, R.sup.1 and R.sup.2 are as stated above) to hydrolysis after or without isolation and if desired converting the compound of the Formula I thus obtained into a salt thereof or setting free the same from its salt. The compounds of the Formula I are known antibacterial agents.

A method of using a compound of the Formula (V) ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, wherein R.sup.1 and R.sup.2 are each C.sub.1 to C.sub.6 aliphatic acyloxy, unsubstituted or substituted by halogen, or are each C.sub.7 to C.sub.11 aromatic acyloxy, for preventing amination of the 6-position when a compound of the Formula (I) ##STR2## or a pharmaceutically acceptable salt thereof is to be formed, which comprises the steps of:

Process for the preparation of quinoline carboxyolic acids

The present invention relates to novel 4-oxo-4H-pyrido[1,2-a]pyrimidine -3-carbonamide derivatives of the general formula (I) and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I) ##STR1## wherein: R stands for a C.sub.1-12 alkyl group optionally substituted by a C.sub.1-4 alkoxycarbonyl group; a C.sub.3-9 cycloalkyl, adamantyl or optionally substituted phenyl group;

Pyridopyrimidine derivatives useful in treatment of ulcers

Baron chelates of quinoline carboxylic acids

The invention relates to a new process for the preparation of compounds of the Formula I ##STR1## (wherein R stands for hydrogen or methyl) and pharmaceutically acceptable salts thereof which comprises reacting a compound of the Formula V ##STR2## (wherein R.sup.1 and R.sup.2 stand for an aliphatic acyloxy group comprising 2-6 carbon atoms and optionally substituted by halogen; or for an aromatic acyloxy group comprising 7-11 carbon atoms) with an amine of the Formula VI ##STR3## (wherein R has the same meaning as stated above) or a salt thereof and subjecting the compound of the Formula VII ##STR4## thus obtained (wherein R, R.sup.1 and R.sup.2 are as stated above) to hydrolysis after or without isolation and if desired converting the compound of the Formula I thus obtained into a salt thereof or setting free the same from its salt. The compounds of the Formula I are known antibacterial agents. The advantage of the process of the present invention is that it makes the desired compounds of the Formula I available in a simple manner, with high yields and in a short reaction time.

Quinoline carboxylic acid boric acid anhydrides

1-Methylamino-quinoline-carboxylic acid derivatives

A new method of treatment is disclosed for a vascular obstructive lesion resulting from restricted blood circulation, characterized by an erythrocyte pathology, in an effected animal subject. The new method involves the administration of 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4-dihydroisoquinolinium-theophylli ne-7-acetat e, in a dosage and at a rate sufficient to maintain a blood concentration of at least 0.5 to at most 3 .gamma./ml, calculated on the basis of 1-(3',4'-diethoxybenzyl)-6,7-diethoxy-3,4-dihydroisoquinoline.

Method of treating a vascular obstructive lesion resulting from

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Budapest, Hungary

Agnes Horvath