Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Agnes Gottsegen

Sandor Antus

Mihaly Nogradi

Gabor Kovacs

Dezso Korbonits

Laszlo Feuer

Lorant Farkas

Borbala Vermes

Lorand Farkas

Sandor Virag

Jozsef Knoll

Jozsef Szejtli

Gergely Heja

Laszlo Tardos

Katalin Marmarosi Nee Kellner

Gabor Horvath

Katalin Marmarosi

Peter S Kormoczy

Vera Gergely

Jeno Marton

Todor Pfliegel

Emil Minker

Andras Wolfner

Lorand Debreczeni

Zoltan Vargai

Janos Streliszky

Andreas Wolfner

Maria Kovaks

Agnes Stadler

Zsuzsa Furst

Andrea Bolehovszky

The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I ##STR1## and pharmaceutically acceptable salts thereof wherein A stands for C.sub.1-4 alkylene and

Oxadiazole-alkyl-purine derivatives useful as antitussive agents

2,6-di-O-methyl-beta-cyclodextrin complexes of compounds of the formula (1a) ##STR1## wherein R.sup.2' stands for C.sub.1 to C.sub.12 alkyl or a group of the formula ##STR2## in which R.sup.11 is C.sub.1 to C.sub.4 alkyl;

Dibenzo[bd]pyran derivatives, process for the preparation thereof and

Nonestrogenic 5-methyl-alkoxy-isoflavone, namely, 5-methyl-7-methoxy-isoflavone, 5-methyl-7-ethoxy-isoflavone, 5-methyl-7-isopropoxy-isoflavone, and 5-methyl-7-(2-hydroxy-ethoxy)-isoflavone are useful as weight-gain promoters in feeds from which the 7-methoxy and 7-ethoxy isoflavones have been excluded because of estrogenic effects. They are more effective than 7-isopropoxy-isoflavone as well.

Metabolic 5-methyl-isoflavone-derivatives, process for the preparation

Compounds of the formula (1), or their salts, ##STR1## are prepared as follows: (A) A COMPOUND OF THE FORMULA (II) ##STR2## is reduced; or (B) A COMPOUND OF THE FORMULA (III) ##STR3## is reacted, e.g. after protecting the phenolic hydroxy group attached to position 3 of the ring, with a compound of the formula (IV), ##STR4## or (C) GROUP R.sup.1 of a compound of the formula (V) ##STR5## is removed in an acidic medium, AND, IF DESIRED, THE COMPOUND OF THE FORMULA (I) is converted into salt, or a salt of a compound of the formula (I) is converted into the free acid or another salt thereof. The compounds of the formula (I) and their salts are valuable artificial sweetening agents. In the above formulae

Acyl-phenoxy-propanesulfoacids and salts, and artificial sweetening

A sweetening agent in the form of a 1,3-diphenyl-propanone-1 derivative of the formula ##SPC1## Wherein R is hydrogen, hydroxyl, alkoxy or carboxyl-substituted, sulphonyl-substituted, phosphonyl-substituted, dialkylamino-substituted, trialkyl ammonium-substituted alkoxy; R.sup.1 is hydrogen or a hydrophylic group but both R and R.sup.1 are not both hydrogen; R.sup.2 and R.sup.3 are hydroxyl or alkoxy.

1,3-Diphenyl-propanone-1-derivatives and the salts thereof

A method of anabolic treatment in humans comprises administering a compound of the following formula: ##SPC1## Wherein R is halosubstituted, nitrosubstituted, or unsubstituted benzyl, R.sup.2 is hydrogen, methyl or carboxy, and R.sup.3 and R.sup.4 are hydrogen, methoxy or nitro. Pharmaceutical compositions are also disclosed.

Anabolic-weight-gain promoting compositions containing isoflavone

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Budapest, Hungary

Agnes Gottsegen