Jouveinal, S.a.

Institut De Recherche Jouveinal S.a.

Sipsy

Institute De Recherche Jouveinal

Agnes G Grouhel

Jean-Louis Junien

Gilbert G Aubard

Xavier B Pascaud

Claude P Roux

Dieran R Torossian

Alain P Calvet

Jacques Bure

Alain A Calvet

Henri Jacobelli

Claude J Gouret

Laurent Diop

Francois J Roman

Annick Langlois

Veronique J Lelievre

Allylaminoesters of the formula (I): ##STR1## in which: R.sub.1 is H or low-molecular-weight alkyl,

Allylaminoesters and their application in therapeutics

Process for the treatment of painful syndromes, especially local and/or visceral, consisting in the parenteral or topical administration of a therapeutically effective quantity of the (-) tartrate of (+)-(R)-1-[(3,4,5-trimethoxy)benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-prop ylamine.

Analgesic properties of fedotozine

Enantiomers of (S) configuration of formula (I) ##STR1## in which R is H or methyl, with antiallergic and in particular antihistaminic activity, useful as medicinal products.

Enantiomers derived from (S)-2-amino-2-(3,4-dichlorobenzyl)-1-propanol,

(+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propylam ine of formula ##STR1## is a medicament of use in gastroenterology.

Use of

The present invention relates to propanamines of general formula (I) ##STR1## in which: R1 is a phenyl radical optionally mono-, di- or trisubstituted in an identical or different manner with halogen atoms, or lower alkyl, lower haloalkyl or lower alkoxy radicals; R2 is a lower alkyl radical, R3 and R4 are a hydrogen atom or a lower alkyl, lower alkenyl or lower cycloalkyalkyl radical, R5 is a 5-to 7-membered cycloalkyl radical or a phenyl radical, and W represents a heterocycle .dbd.C[Q--(CH.sub.2).sub.n --Q] in which Q is an oxygen or sulfur atom and n is 2 or 3, and their acid addition salts with pharmaceutically acceptable acids. The invention also relates to antidiarrheal pharmaceutical compositions comprising the claimed propanamines.

Propanamines, their pharmacological properties and their application as

A compound which is a propanamine of general formula (I) ##STR1## in which: R1 is a phenyl radical optionally mono-, di- or trisubstituted,

Propanamines, their pharmacological properties and their application for

3,20-dione-11.beta.-hydroxypregn-4-ene-21-thioacetate-17-butyrate and 3,20-dione-11.beta.-hydroxypregn-4-ene-21-thiopropionate-17-butyrate, are anti-inflamatory agents.

Hydrocortisone-17-oxo-21-thioesters, their preparation and their uses as

Aminoalcohols of formula: ##STR1## in which R.sub.1 is alkyl, R.sub.2 H or alkyl, R.sub.3 in particularly H, alkyl, phenylakyl, alkanoyl, phenylalkanoyl, in which N, R.sub.2 and R.sub.3 together form a heterocycle saturated with 5 to 7 chain links. Analgesic medicaments.

Aminoalcohols, their preparation process and their applications,

3,20-dione-11.beta.-hydroxypregn-4-ene-21-thioacetate-17-butyrate and 3,20-dione-11.beta.-hydroxypregn-4-ene-21-thiopropionate-17-butyrate, are anti-inflammatory agents.

Hydrocortisone 17-oxo-21-thioesters and their uses as medicaments

Aminoethyl imidazole of formula: ##STR1## in which R.sub.1 is a lower alkyl, R.sub.2 is a phenyl or phenoxy radical, optionally substituted by a halogen atom or a lower alkoxy radical, R.sub.3,R.sub.4 and R.sub.5 are a hydrogen atom or a lower alkyl radical and x, y and z have the value 0 or 1, but the values of y and z cannot be the same, together with their acid addition salts with acids. Cytoprotective medicament.

Aminoethylimidazole and cytoprotective and gastric antisecretory

Compounds of formula: ##STR1## wherein A and B each represent, independently of each other, a straight-chained or branched alkyl group having from 1 to 6 carbon atoms or a phenyl group optionally mono- or polysubstituted by alkyl radicals having from 1 to 6 carbon atoms, alkoxy groups having from 1 to 6 carbon atoms or halogen, T and U, independently of each other, represent hydrogen atoms or together form a double bond, V is a hydrogen atom or a methyl group at the .alpha.-position, W is a hydrogen atom or a halogen atom at the .alpha.-position, X is a hydroxy group at the .beta.-position and Y is a hydrogen atom or X and Y may together represent an oxygen atom, and Z.sub.1 is a hydrogen atom, a methyl group at the .alpha.- or .beta.-position, while Z.sub.2 is a hydrogen atom, or Z.sub.1 and Z.sub.2 together form a methylene group. These compounds have anti-inflammatory activity.

Growing community of inventors

Meudon, France

Agnes G Grouhel