Galderma S.a.

Centre International De Recherches Dermatologiques Galderma

Centre International De Recherches Dermatologiques Gladerma

Agnes Ferrandis

Josiane Allec

Isabelle Preuilh

Nathalie Willcox

Sandrine Orsoni

Laurent Fredon

Nathalie Wilcox

Topically applicable dermatological/cosmetic compositions suited for ungual/peri-ungual administration for the treatment of a variety of pathologies, including fungal pathologies, such as onychomycosis, contain (a) at least one biologically active agent (e.g., antifungal) and (b) at least two of the pro-penetrating agents selected from the group consisting of urea, an organic acid and an ethoxydiglycol, the at least two-pro-penetrating agents respectively being present in effective amounts as to synergistically improve the ungual/peri-ungual bioavailability of the at least one biologically active agent.

Synergistically pro-penetrating solutions for ungual/peri-ungual dermatological/cosmetic applications

Topically applicable cosmetic/dermatological compositions well suited for the therapeutic treatment or care of human skin, nails, hair and/or of the scalp, in particular for treating and/or preventing xerosis, ichthyosis, actinic keratosis and/or photoinduced cutaneous aging, comprise a water-in-oil emulsion containing (a) at least 10% by weight of at least one hydroxy acid, (b) an effective emulsifying amount of at least one polyoxyalkylenated silicone, and (c) an effective coemulsifying amount of at least one polyol alkyl ester, polyol alkyl ether or oxyalkylenated alkyl ether, with the proviso that the subject compositions are devoid of any C.sub.1 -C.sub.4 alkanol.

Cosmetic/dermatological w/o emulsions highly concentrated in hydroxy

Growing community of inventors

Mougins, France

Agnes Ferrandis