Centre National De La Recherche Scientifique

National Institute for Agricultural Research

Agnes Delmas

Vincent Aucagne

Oleg Melnyk

Laurent Raibaut

Massimiliano Beltramo

Mathieu Galibert

Alain Caraty

A KISS1R agonist peptide compound capable of inducing ovulation in a female mammal is provided. The compound is a pseudopeptide having the C-terminal sequence: -Xaa&#x3a8;[Tz]Xaa2-Xaa3-Xaa4-NH(SEQ ID NO: 3), where &#x3a8;[Tz] represents a 1,4-disubstituted 1,2,3-triazole group replacing the peptide bond between the Xaa1 residue and the Xaa2 residue, Xaa1 is Gly or Ala, Xaa2 is Leu or an aliphatic &#x3b1;-aminoacyl analog residue, Xaa3 is Arg, Arg(Me) or a positively charged &#x3b1;-aminoacyl analog residue, and Xaa4 is Tyr, Phe, Trp or an &#x3b1;-aminoacyl analog residue such as aryl alanine; or an analog of the pseudopeptide in which the amide peptide bond between Xaa2 and Xaa3 and/or between Xaa3 and Xaa4 is replaced with an isosteric bond, or a salt thereof.

KISS1R receptor agonist compounds and use thereof for inducing ovulation in mammals

Method for assembling proteins from peptide fragments. It allows the production of proteins in a manner that is simple, reliable and applicable on an industrial scale. This method allows the production of proteins of therapeutic or diagnostic interest. The invention also relates to kits for applying this synthesis method as well as test and/or diagnostic kits.

Method for synthesizing proteins

The invention relates to compounds which can be used for purifying peptides produced by solid phase peptide synthesis. In addition, the invention relates to methods for purifying peptides produced by solid phase peptide synthesis using the compounds according to the invention.

Compounds and methods for purifying peptides produced by solid phase peptide synthesis

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Orleans, France

Agnes Delmas