Hetero Research Foundation

Hetero Labs Limited

Adulla Venkat Narsimha Reddy

Bandi Parthasaradhi Reddy

Kura Rathnakar Reddy

Bandi Vamsi Krishna

Dasari Muralidhara Reddy

Rapolu Raji Reddy

The present invention relates to a process for preparing amorphous form of Sacubitril/Valsartan sodium salt of Formula-II and pharmaceutical composition comprising thereof. 

Process for the preparation of a dual-acting angiotensin receptor-neprilysin inhibitor compound

The present invention provides an improved process for the preparation of 4&#x3b1;-acetoxy-2&#x3b1;-benzoyloxy-5&#x3b2;,20-epoxy-1&#x3b2;,13&#x3b1;-dihydroxy-7&#x3b2;,10&#x3b2;-dimethoxy-9-oxo-11-taxene (7&#x3b2;,10&#x3b2;-dimethoxy-10-deacetoxybaccatin III). The present invention also provides a novel process for the preparation of cabazitaxel.

Process for cabazitaxel

The present invention provides a novel process for the preparation of rilpivirine. The present invention also provides a novel process for the preparation of rilpivirine hydrochloride. The present invention further provides a rilpivirine hydrochloride monohydrate, process for its preparation and pharmaceutical compositions comprising it.

Rilpivirine hydrochloride

The present invention provides a commercially viable process for preparing rilpivirine and its pharmaceutically acceptable acid addition salts thereof in high yields using novel intermediate.

Process for rilpivirine using novel intermediate

The present invention provides a novel process for the preparation of 4-(4-hydroxypyrimidin-2-ylamino)benzonitrile. The present invention also provides a novel process for the preparation of 4-iodo-2,6-dimethyl benzenamine. The present invention further provides an improved process for the preparation of rilpivirine. The present invention further provides a tosylate salt of rilpivirine, process for its preparation and pharmaceutical compositions comprising it.

Process for rilpivirine

4-[[6-chloro-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethyl-benzonitrile is a key intermediate for the preparation of etravirine. The present invention provides a process for preparation of 4-[[6-chloro-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile. The present invention also provides a novel process for the preparation of etravirine crystalline form I. The present invention further provides novel crystalline forms of etravirine, processes for their preparation and pharmaceutical compositions comprising them.

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Hyderabad Telangana, India

Adulla Venkat Narsimha Reddy