Johns Hopkins University

University of Debrecen

Adrienne Csutak

David M Silver

Andras Berta

Jozsef Tozser

József Tözsér

András Berta

Gabriella Miklóssy

A light source is situated on a headgear device and placed to direct light toward the pupil of the eye at an intensity that causes the iris to constrict, resulting in a smaller pupil. This prevents the light scattering due to ophthalmic surgery or eye injury from entering the eye, thereby reducing or eliminating visual aberrations.

Method and apparatus for reducing visual aberrations

The present invention is directed to a method to prevent or reduce postoperative corneal subepithelial haze after excimer laser photorefractive keratectomy (PRK), laser in situ keratomileusis (LASIK) surgery. According to the method, a therapeutically effective amount of one or more plasminogen activators, most preferably urokinase (uPA), is administered topically to the surface of the affected eye at levels between 0.1 and 2,500 IU/ml, about eight to twelve times on the day of surgery, and four to eight times per day for about the next six to twelve days thereafter. The most preferred therapeutic amount is from about 0.1&#x2013;1 IU uPA/ml, and also 1&#x2013;10 IU/ml. Plasminogen activators that can be used in the inventions include urokinase, prourokinase, streptokinase and mutants thereof. The invention also covers topical ophthalmic compositions that include one or more plasminogen activators, most preferably uPA, to prevent or reduce postoperative corneal subepithelial haze.

Plasminogen activator to prevent corneal and subepithelial haze after laser vision correction surgery

Growing community of inventors

Debrecen, Hungary

Adrienne Csutak