Sanofi-aventis

Sanofi

Mitsubishi Pharma Corporation

Sanofi-synthelabo

Adrien Tak Li

Antonio Almario Garcia

Christian Hoornaert

Ahmed Abouabdellah

Philippe Burnier

Gihad Dargazanli

Frederic Puech

Florence Medaisko

Pascal George

Michele Bas

Yulin Chiang

Kazutoshi Watanabe

Alistair Lochead

Mourad Saady

Philippe Yaiche

Jonathan Reid Frost

Zhongli Gao

Alain Nedelec

Thierry Gallet

Ryoichi Ando

Fumiaki Uehara

Roy J Vaz

Aya Shoda

Sylvain Cote Des Combes

Alain Gueiffier

Keiichi Arimoto

Qiuxia Zhao

Matthieu Barrague

Séverine Marguerie

Frédéric Puech

Mathieu Barrague

Cecile Enguehard-Gueiffier

Antonio Almario-Garcia

Antonio Almario Carcia

Cécile Enguehard

Frederic Peuch

The invention relates to the 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R, R, R, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.

6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]-pyridazine and derivatives thereof preparation and therapeutic application thereof

The invention relates to the 6-cycloamino-3-(pyridin-4-yl)imidazo[I,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R, R, R, R, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.

6-cycloamino-3-(pyrid-4-yl)imidazo[1,2-b]pyridazine derivatives, preparation thereof and therapeutic use thereof

6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine and derivatives and pharmaceutical compositions comprising the same

A compound corresponding to general formula (I): in which Rrepresents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C-C)alkyl, (C-C)alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C-C)cycloalkyl-O&#x2014; or (C-C)cycloalkyl(C-C)alkoxy groups; Rrepresents either a group of general formula CHRCONHRin which Rrepresents a hydrogen atom or a methyl group and Rrepresents a hydrogen atom or a (C-C)alkyl, (C-C) cycloalkyl or (pyridin-4-yl)methyl group; or a 2,2,2-trifluoroethyl group; or an (imidazol-2-yl)methyl group; or a (benzimidazol-2-yl)methyl group; or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, (C-C)alkyl, (C-C)alkoxy, trifluoromethyl or trifluoromethoxy groups; and n represents a number ranging from 1 to 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Also disclosed and claimed are the pharmaceutical compositions derived therefrom and their therapeutic use in treating a wide variety of diseases.

Derivatives of dioxan-2-alkyl carbamates, preparation thereof and application thereof in therapeutics

The invention relates to a compound having general formula (I): Wherein m, Rand Rare as defined herein. The invention also relates to the use of the compound in therapeutics. More specifically, the compounds of the invention are inhibitors of the FAAH enzyme, and therefore, can be used for the treatment of various disorders associated with FAAH enzyme, which include in a non-limiting manner, pain, eating disorders, neurological and psychiatric pathologies, among other disorders.

Derivatives of 1-piperazine- and 1-homopiperazine-carboxylates, preparation method thereof and use of same as inhibitors of the FAAH enzyme

A compound corresponding to general formula (I): in which Rrepresents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C-C)alkyl, (C-C)alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C-C)cycloalkyl-O&#x2014; or (C-C)cycloalkyl(C-C)alkoxy groups; Rrepresents either a group of general formula CHRCONHRin which Rrepresents a hydrogen atom or a methyl group and Rrepresents a hydrogen atom or a (C-C)alkyl, (C-C)cycloalkyl or (pyridin-4-yl)methyl group; or a 2,2,2-trifluoroethyl group; or an (imidazol-2-yl)methyl group; or a (benzimidazol-2-yl)methyl group; or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, (C-C)alkyl, (C-C)alkoxy, trifluoromethyl or trifluoromethoxy groups; and n represents a number ranging from 1 to 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Also disclosed and claimed are the pharmaceutical compositions derived therefrom and their therapeutic use in treating a wide variety of diseases.

Derivatives of 1-piperazine-and 1-homopiperazine-carboxylates, preparation method thereof and use of same as inhibitors of the FAAH enzyme

The invention relates to therapeutic uses of a pyrimidone derivative represented by formula (I) or a salt thereof:  Wherein X, Y, R1, R2, m and n are as defined herein. Specifically, a medicament comprising the said derivative or a salt thereof as an active ingredient is used for preventive and/or therapeutic treatment of a neurodegenerative diseases caused by abnormal activity of GSK3&#x3b2; such as Alzheimer's disease.

[object Object]

The invention relates to a compound of formula (I): Wherein R, R, Rand Rare as defined herein. The invention also relates to methods of preparation of compounds of formula (I) as well as to their therapeutic application.

Alkyl-, alkenyl- and alkynylcarbamate derivatives, their preparation and their application in therapeutics

A pyrimidone derivative represented by formula (I) or a salt thereof: Wherein: And a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3&#x3b2; such as Alzheimer's disease.

2-amino-3-(alkyl)-pyrimidone derivatives

A compound corresponding to general formula (I): in which Rrepresents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C&#x2013;C)alkyl, (C&#x2013;C)alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C&#x2013;C)cycloalkyl-O&#x2014; or (C&#x2013;C)cycloalkyl(C&#x2013;C)alkoxy groups; Rrepresents either a group of general formula CHRCONHRin which Rrepresents a hydrogen atom or a methyl group and Rrepresents a hydrogen atom or a (C&#x2013;C)alkyl, (C&#x2013;C)cycloalkyl or (pyridin-4-yl)methyl group; or a 2,2,2-trifluoroethyl group; or an (imidazol-2-yl)methyl group; or a (benzimidazol-2-yl)methyl group; or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, (C&#x2013;C)alkyl, (C&#x2013;C)alkoxy, trifluoromethyl or trifluoromethoxy groups; and n represents a number ranging from 1 to 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Also disclosed and claimed are the pharmaceutical compositions derived therefrom and their therapeutic use in treating a wide variety of diseases.

Derivatives of dioxane-2-alkyl carbamates, preparation thereof and application thereof in therapeutics

Imidazo[1,2-&#x3b1;]pyrimidinones and pyrimido[1,2-&#x3b1;]pyrimidinones useful for preventive and/or therapeutic treatment of neurodegenerative diseases, such as Alzheimer's disease, caused by abnormal GSK3&#x3b2; activity.

2-pyridinyl-6,7,8,9-tetrahydropyrimido{1,2-a}pyrimidin-4-one and 7-pyridinyl-2,3-dihydoimidazo{1,2-a}pyrimidin-5(1H)one derivatives

A pyrimidone derivative represented by formula (I) or a salt thereof: And a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3&#x3b2; such as Alzheimer's disease.

2-amino-3-(alkyl)-pyrimidone derivatives as GSK3.&#x3b2;.inhibitors

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Fontenay aux Roses, France

Adrien Tak Li