Medtronic, Inc.

Enteromedics Inc.

Reshape Lifesciences Inc.

Venturi Group, LLC

Flathead Partners, LLC

Adrianus P Donders

Mark B Knudson

Jonathan J Waataja

Koen Jacob Weijand

Katherine S Tweden

Bozidar Ferek-Petric

Markus Haller

Timothy R Conrad

Vineel Vallapureddy

Satish Ramadhyani

Wu Wang

Hang Chan

Beth Anne Guck

Keith Alan Miesel

James Kevin Carney

Matthew David Bonner

Mark A Christopherson

Kenneth B Stokes

Richard P M Houben

Robert Leinders

Michael R Ujhelyi

Craig L Wiklund

Arnold W Thornton

Len D Twetan

Sarah Anne Audet

Jason William Sprain

Mark Raymond Stultz

Gregory Pat Spar

Scott Anthony Lambert

Terence G Ryan

Janell M Gottesman

Keon J Weijand

Beth A Hassler

John W St Ores

Curtis D Deno

Mark A Christophersom

John Charles Laughlin

Koen J Weijand

Richard PM Houben

A method of downregulating and/or upregulating neural activity by applying a high frequency alternating current electrical signal to a nerve in a subject is disclosed. The signal comprises more than one microsecond cycle comprising one or more periods, each period comprising a charge recharge phase, and optionally, a pulse delay, each period having a frequency of at least 1000 Hz; and a microsecond inactive phase. In embodiments, an electrical signal treatment comprises more than one microsecond cycle to form a millisecond cycle, each millisecond cycle separated by a millisecond inactive phase during an on time. In embodiments, the electrical signal patterns can differ in amplitude.

High-frequency low duty cycle patterns for nerual regulation

A method and apparatus are disclosed for treating a variety of conditions include treating a disorder associated with neural activity near a region of a brain. In such condition, the method includes placing an electrode to create a field near said region, creating said field with parameters selected to at least partially block neural activity within said field. For treating a tissue sensation, the method includes identifying a target area of tissue to be treated and placing an electrode to create a field near the target area, and creating the field with parameters selected to at least partially block neural activity within the target area. For treating a condition associated with neural activity of a spinal cord, the method includes placing an electrode to create a field near a nerve associated with the spinal cord, and creating the field with parameters selected to at least partially block neural activity within the nerve.

Neural blocking therapy

High-frequency low duty cycle patterns for neural regulation

A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency.

Neural modulation devices and methods

A therapy system for applying an electrical signal to an internal anatomical feature of a patient includes an implantable component and an external component. The implantable component is configured to receive a selected therapy program and a selected therapy schedule from the external component. The implantable component is adapted to be selectively configured into one of a training mode and a delivery mode. The implantable component is configured to apply therapy to the internal anatomical feature in accordance with the selected therapy program and the selected therapy schedule when configured in the delivery mode. The implantable component is configured to simulate application of therapy when configured in the training mode.

Implantable therapy system having multiple operating modes

A treatment system includes a regulator implanted within a patient, a computing device storing at least one patient database associated with the patient in whom the regulator is implanted, and a data transfer device. The data transfer device provides bi-directional communication (e.g., voice communication) and a data exchange (e.g., a treatment history, a patient database, and operational instructions) between the regulator and the computing device. A programmer can obtain patient reports and/or default treatment values from the computing device based on the data exchange.

Remote monitoring and control of implantable devices

Example embodiments of an implantable device are configured to be implanted within a patient to provide medical therapy to the patient. In general, an implantable rechargeable device includes a rechargeable battery and an electronic board assembly arranged within a case and an antenna electrically coupled to the rechargeable battery. The antenna is configured to receive power and to transfer at least a portion of the received power to the rechargeable battery for recharging. A phase change material is arranged within the case around at least a portion of the electronic board assembly. The phase change material is configured to transition from a first phase to a second phase at a transition temperature when the insulating material absorbs heat (e.g., from the electronic board assembly).

Implantable device with heat storage

A therapy system for applying an electrical signal to an internal anatomical feature of a patient includes an implantable component and an external component. The external component can be configured into one of multiple selectable operating modes. The therapy system also may include a first external antenna configured to communicate with the implantable component and a second external antenna configured to communicate with the implantable component. Plugging one of the external antennas into the external component automatically configures the external component into one of the operating modes.

Implantable therapy system with external component having multiple operating modes

An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.

Neural electrode treatment

A treatment system includes a regulator implanted within a patient, a computing device storing at least one patient database associated with the patient in whom the regulator is implanted, and a data transfer device. The data transfer device provides bidirectional communication (e.g., voice communication) and a data exchange (e.g., a treatment history, a patient database, and operational instructions) between the regulator and the computing device. A programmer can obtain patient reports and/or default treatment values from the computing device based on the data exchange.

A data collection system includes remote, implantable sensors for monitoring one or more patient parameters, collecting and processing data from those sensors and utilizing that data in the performance of a clinical study of a drug or other pharmacological agent. The system assists with preparation of a protocol for a clinical trial; presentation of that protocol; assuring compliance with the protocol; and generating useful results from data collected via the system and externally for presentation to an approval forum.

Integrated data collection and analysis for clinical study

Growing community of inventors

Andover, MN, United States of America

Adrianus P Donders